Hi Susan,

On Thu, 2015-11-19 at 20:52 +0000, Susan Beth Fogelson wrote:
> I am using Mauve to align approximately 35 bacterial genomes to a
> reference.  Currently I am using a desktop computer with 16GB of RAM.
> I started the alignment about 2 days ago and it is still running, is
> this a normal time frame?  Is there a way I can let the program access
> more memory to have it run more efficiently or do you suggest I use a
> computer with more power?  


You should be able to determine if progressiveMauve is running out of
memory by looking at a task/process manager. If on linux you could try
top, on windows the task manager (via Ctrl+Alt+Esc) or on mac the
"Activity Monitor" from the utilities folder. If you see a lot of disk
activity, or that the progressiveMauve process is running at much less
than 100% CPU, combined with a allocated memory footprint (VM size)
approaching your system memory size, then it is likely the program needs
more memory.

If you don't see those symptoms then it's probably already going as fast
as it can as currently implemented. progressiveMauve runs
single-threaded (e.g. no multi-core CPU support) and a few days of
compute does not sound unusual for a dataset of the size you describe. 

Best,
-Aaron

-- 
Aaron E. Darling, Ph.D.
Associate Professor, ithree institute
University of Technology Sydney
Australia

http://darlinglab.org
twitter: @koadman




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