The following message is official and has been approved by the
appropriate authorities to be posted to this list.
Student Position Description
LBNL Life Sciences Division
Department of Cell and Molecular Biology
Cooper Lab
Project Description:
DNA damage from environmental sources as well as from the cellular
metabolism itself threatens the integrity of the genome if not
detected and removed. Studies in the Cooper laboratory are directed
toward understanding the biochemical and molecular basis for the
processing of damaged DNA and the genetic control of these repair
processes in mammalian cells. Many human genetic diseases that
involve defects in DNA repair are associated with severe
developmental, neurological and immunological abnormalities as well
as frequent cancer predisposition. We are investigating the
possibility that these symptoms are related to damage to DNA from
reactive oxygen species generated during metabolism.
The approaches we are using in this project include a combination of
protein biochemistry, molecular biology, cell biology, and structural
biology.
Student Role and Opportunities for Learning:
The student will work with a postdoctoral scientist in
the laboratory to provide assistance with ongoing projects. The
student will gain familiarity with a basic research environment in
the molecular life sciences, learn to work as part of an integrated,
highly active research team, and be introduced to central current
concepts in mammalian molecular and cell biology, particularly with
respect to processes necessary for preserving the integrity of the
genome. The student will learn mammalian cell culture and will gain
knowledge of a wide variety of molecular and biochemical techniques.
A minimum of 10 hours a week will be required in order for the
student to get the maximum benefit from the experience.
Required Academic Background:
A strong background in molecular biology, biochemistry,
genetics, or related discipline, together with relevant laboratory
experience (which may be course-related) will be essential to take
full advantage of the research opportunities in the Cooper lab.
Contact Information:
Dr. Helen Budworth
Life Sciences Division
Tel: (510) 486-6113
Building 74, Room 303
Email: <mailto:[EMAIL PROTECTED]>[EMAIL PROTECTED]
LBNL
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<div>Approved: mcbrules</div>
<div>From: Helen Budworth <[EMAIL PROTECTED]></div>
<div>Subject: Student position - LBNL Life Sciences Division</div>
<div align="center"><b><br></b></div>
<div align="center"><b><br></b></div>
<div align="center"><b>Student Position Description</b><br>
</div>
<div align="center"><b>LBNL Life Sciences Division</b><br>
</div>
<div align="center"><b>Department of Cell and Molecular
Biology</b><br>
</div>
<div align="center"><b>Cooper Lab</b><br>
</div>
<div align="center"> <br>
</div>
<div><u>Project Description:</u><br>
</div>
<div>DNA damage from environmental sources as well as from the
cellular metabolism itself threatens the integrity of the genome if
not detected and removed. Studies in the Cooper laboratory
are directed toward understanding the biochemical and molecular basis
for the processing of damaged DNA and the genetic control of these
repair processes in mammalian cells. Many human genetic diseases
that involve defects in DNA repair are associated with severe
developmental, neurological and immunological abnormalities as well as
frequent cancer predisposition. We are investigating the
possibility that these symptoms are related to damage to DNA from
reactive oxygen species generated during metabolism.<br>
</div>
<div>The approaches we are using in this project include a combination
of protein biochemistry, molecular biology, cell biology, and
structural biology.<br>
</div>
<div><u>Student Role and Opportunities for Learning:</u><br>
</div>
<div>
The student will work with a postdoctoral scientist in the laboratory
to provide assistance with ongoing projects. The student will gain
familiarity with a basic research environment in the molecular life
sciences, learn to work as part of an integrated, highly active
research team, and be introduced to central current concepts in
mammalian molecular and cell biology, particularly with respect to
processes necessary for preserving the integrity of the genome.
The student will learn mammalian cell culture and will gain knowledge
of a wide variety of molecular and biochemical techniques. A
minimum of 10 hours a week will be required in order for the student
to get the maximum benefit from the experience.<br>
</div>
<div><u>Required Academic Background:</u><br>
</div>
<div>
A strong background in molecular biology, biochemistry, genetics, or
related discipline, together with relevant laboratory experience
(which may be course-related) will be essential to take full advantage
of the research opportunities in the Cooper lab.<br>
</div>
<div><u><b>Contact Information:</b></u><br>
</div>
<div><b>Dr. Helen Budworth</b><br>
</div>
<div>Life Sciences
Division <span
></span
> <span
></span
> <span
></span
> <span
></span>
Tel:
(510) 486-6113<br>
</div>
<div>Building 74, Room
303 <span
></span
> <span
></span
> <span
></span>
Email:
<a href="mailto:[EMAIL PROTECTED]">[EMAIL PROTECTED]</a><br>
</div>
<div
>LBNL <span
></span
> <span
></span
> <span
></span
> <span
></span
> <span
></span
> <span
></span> </div>
</body>
</html>
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