There are 5 messages in this issue.
Topics in this digest:
1. MEDICAL: RESEARCH : MEDICAL: DISEASES: CANCER: Researchers Discover
From: David P. Dillard
2. ELDERLY AGING GERONTOLOGY GERIATRIC: HEALTH MEDICAL FITNESS DIET: Ne
From: David P. Dillard
3. Policy Post 12.22: CDT and PFF Urge Courts to Rein in the FCC
From: David P. Dillard
4. COMPUTER: SECURITY : EDUCATION: COLLEGE: COMPUTER: Major Breach of
From: David P. Dillard
5. Radio station for Rs 5,000 = $Can 128.35 = U$ 111.86
From: George Lessard
Messages
________________________________________________________________________
1. MEDICAL: RESEARCH : MEDICAL: DISEASES: CANCER: Researchers Discover
Posted by: "David P. Dillard" [EMAIL PROTECTED] jwneastro
Date: Mon Dec 11, 2006 11:23 am ((PST))
MEDICAL: RESEARCH :
MEDICAL: DISEASES: CANCER:
Researchers Discover Method in Mice to Restore Tamoxifen Sensitivity in
Resistant Breast Cancer
Date: Mon, 11 Dec 2006 12:23:22 -0500
From: "NIH OLIB (NIH/OD)" <[EMAIL PROTECTED]>
To: [EMAIL PROTECTED]
Subject: Researchers Discover Method in Mice to Restore Tamoxifen
Sensitivity in Resistant Breast Cancer
U.S. Department of Health and Human Services
NATIONAL INSTITUTES OF HEALTH
NIH News
NIH Office of the Director (OD)
<http://www.nih.gov/icd/od/>
National Cancer Institute (NCI)
<http://www.nci.nih.gov/>
Embargoed for Release: Monday, December 11, 2006 12:00 noon ET
CONTACT: NCI Media Relations Branch, 301-496-6641,
<e-mail: [EMAIL PROTECTED]>
RESEARCHERS DISCOVER METHOD IN MICE TO RESTORE TAMOXIFEN SENSITIVITY IN
RESISTANT BREAST CANCER
The widely used breast cancer drug tamoxifen (Nolvadex®), which can become
less effective over time, might retain its full strength indefinitely if
used along with a second drug, according to new research in mice conducted
by investigators from the National Cancer Institute (NCI), part of the
National Institutes of Health, and their partners. The results appear in
the December 11, 2006, issue of "Cancer Cell"*. Tamoxifen has been used
successfully since the 1970s to treat certain types of breast cancer and
to prevent them from recurring after surgery. Clinicians observed that
tamoxifen treatment initially reduced the rate of recurrence by nearly 50
percent. Over time, however, patients develop resistance to the drug and
tamoxifen loses its effectiveness as a cancer treatment. "Tamoxifen has
been extremely important in the management of breast cancer," said NCI
Director John E. Niederhuber, M.D. "Being able to overcome resistance
would be an important advance." In the study, the research team, led by
William Farrar, Ph.D., of NCI's Center for Cancer Research at Frederick,
Md., found that the effectiveness of tamoxifen in cell cultures and in
mice can be fully restored by the use of a compound called disulfide
benzamide, or DIBA. The investigators confirmed their study hypothesis
about DIBA's effect on tamoxifen resistance by using the compound in mice
that were engineered to have tamoxifen-resistant tumors and saw that tumor
growth was reduced by nearly 50 percent when DIBA was administered.
"Exposure to DIBA causes certain physical changes to occur between the
estrogen receptor and the biological machinery that stimulates cell
division. By coincidence, these changes also restore the estrogen receptor
to a form that makes it vulnerable once again to tamoxifen," said Li Hua
Wang, Ph.D., lead author of the study. Some, but not all, breast cancer
cells have specific receptors that bind estrogen molecules circulating in
the bloodstream. When estrogen binds to the estrogen receptor, it triggers
a series of events that promote cell division. If the cell is a breast
cancer cell, this interaction leads to tumor growth. In women with
estrogen receptor-positive cancers, cancer cell growth is strongly
influenced by estrogen. Tamoxifen works by binding to estrogen receptors
in place of estrogen and blocking the signals that lead to cell division.
Initially, tumor growth slows or stops altogether. With continued
tamoxifen treatment, however, the estrogen receptor and the
estrogen-dependent signaling pathways in the cell can become altered,
rendering tamoxifen ineffective as an inhibitor. In some cases, tamoxifen
begins to act like estrogen and can stimulate tumor growth. DIBA and
related compounds are being studied because of their ability to disrupt
cellular activity at the genetic level. These so-called electrophilic
compounds were first investigated for possible use against AIDS because
they can block the human immunodeficiency virus (HIV) from replicating.
The HIV studies are ongoing. "This basic study generated exciting
results in our mouse model and suggests a promising approach that might be
tried in human patients," said Farrar. His laboratory is now exploring
ways to produce DIBA in a form that is water soluble so it could be
administered as a pill, the same as tamoxifen. If successful, this could
set the stage for preclinical studies.
Collaborators on the research include Georgetown University, Washington,
D.C., Baylor College of Medicine and The Methodist Hospital, Houston,
Texas, and the National Institute of Allergy and Infectious Diseases,
Bethesda, Md. For more information on Dr. Farrar's research, go to
<http://ccr.cancer.gov/staff/staff.asp?profileid=5618>
For more information about cancer, please visit the NCI Web site at
<http://www.cancer.gov>
or call
NCI's Cancer Information Service
at
1-800-4-CANCER
(1-800-422-6237)
The National Institutes of Health
(NIH) -- The Nation's Medical Research Agency -- is comprised of 27
Institutes and Centers and is a component of the U. S. Department of
Health and Human Services. It is the primary Federal agency for conducting
and supporting basic, clinical, and translational medical research, and
investigates the causes, treatments, and cures for both common and rare
diseases. For more information about NIH and its programs, visit
<http://www.nih.gov>
------
* Wang LH, Yang XY, Zhang X, An P, Kim H, Huang J, Clarke R, Osborne CK,
Inman JK, Appella E, and Farrar WL. Disruption of estrogen receptor
DNA-binding domain and related intramolecular communication restores
tamoxifen sensitivity in resistant breast cancer. "Cancer Cell", December
11, 2006; Vol. 10, Issue 6.
##
This NIH News Release is available online at:
<http://www.nih.gov/news/pr/dec2006/nci-11.html>
Sincerely,
David Dillard
Temple University
(215) 204 - 4584
[EMAIL PROTECTED]
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Messages in this topic (1)
________________________________________________________________________
________________________________________________________________________
2. ELDERLY AGING GERONTOLOGY GERIATRIC: HEALTH MEDICAL FITNESS DIET: Ne
Posted by: "David P. Dillard" [EMAIL PROTECTED] jwneastro
Date: Mon Dec 11, 2006 1:05 pm ((PST))
ELDERLY AGING GERONTOLOGY GERIATRIC: HEALTH MEDICAL FITNESS DIET:
New, Easy-to-Read Booklet Offers Cold-Weather Tips for Older Adults
Date: Mon, 11 Dec 2006 14:07:14 -0500
From: "NIH OLIB (NIH/OD)" <[EMAIL PROTECTED]>
To: [EMAIL PROTECTED]
Subject: New, Easy-to-Read Booklet Offers Cold-Weather Tips for Older
Adults
U.S. Department of Health and Human Services
NATIONAL INSTITUTES OF HEALTH
NIH News
National Institute on Aging (NIA)
<http://www.nia.nih.gov/>
FOR IMMEDIATE RELEASE: Monday, December 11, 2006
CONTACT: Susan Farrer or Linda Joy, 301-496-1752,
<e-mail: [EMAIL PROTECTED]>
NEW, EASY-TO-READ BOOKLET OFFERS COLD-WEATHER TIPS FOR OLDER ADULTS
A new, easy-to-read booklet -- "Stay Safe in Cold Weather!" -- offers
older adults tips on avoiding a dangerous condition called hypothermia.
This free 12-page publication is now available from the National Institute
on Aging (NIA), a part of the National Institutes of Health (NIH).
"Older adults can lose body heat faster than when they were young, and
some health problems and medicines can make it harder for them to stay
warm," says NIA Director Richard J. Hodes, M.D. "This booklet describes
hypothermia and offers simple steps seniors can take to lower their risk
of this sometimes life-threatening health concern." Hypothermia
(hi-po-ther-mee-uh) occurs when a person's body temperature drops below 95
degrees Fahrenheit because of exposure to cold, either indoors or outside.
Low body temperature can cause heart attack, kidney problems, liver damage
and sometimes death. According to the federal Centers for Disease Control
and Prevention, about 600 people in the United States, half of them age 65
or older, die from hypothermia each year. "Stay Safe in Cold Weather!"
is written in plain language and incorporates colorful graphic elements
and other features to help readers understand the content. In creating the
new booklet, the NIA publications team talked with older adults and
considered the needs of people with limited reading skills. "Stay Safe
in Cold Weather!" discusses topics such as: -- What hypothermia is --
How to prevent hypothermia, both in the home and outdoors -- Health
problems that can increase an older person's risk of hypothermia --
Warning signs To order free copies or for more information about "Stay
Safe in Cold Weather!" and other NIA publications, visit the NIA Web site
at
<http://www.nia.nih.gov>
or call
1-800-222-2225
Bulk orders are welcome. The NIA leads the federal effort supporting and
conducting research on aging and the medical, social and behavioral issues
of older people.
The National Institutes of Health (NIH) - The Nation's Medical Research
Agency - is comprised of 27 Institutes and Centers and is a component of
the U. S. Department of Health and Human Services. It is the primary
Federal agency for conducting and supporting basic, clinical, and
translational medical research, and investigates the causes, treatments,
and cures for both common and rare diseases. For more information about
NIH and its programs, visit
<http://www.nih.gov>
##
This NIH News Release is available online at:
<http://www.nih.gov/news/pr/dec2006/nia-11.html>
Sincerely,
David Dillard
Temple University
(215) 204 - 4584
[EMAIL PROTECTED]
Net-Gold
<http://groups.yahoo.com/group/net-gold>
<http://listserv.temple.edu/archives/net-gold.html>
General Internet & Print Resources
<http://library.temple.edu/articles/subject_guides/general.jsp>
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Messages in this topic (1)
________________________________________________________________________
________________________________________________________________________
3. Policy Post 12.22: CDT and PFF Urge Courts to Rein in the FCC
Posted by: "David P. Dillard" [EMAIL PROTECTED] jwneastro
Date: Mon Dec 11, 2006 1:18 pm ((PST))
Date: Mon, 11 Dec 2006 15:16:00 -0500
From: Michael Clark <[EMAIL PROTECTED]>
To: [EMAIL PROTECTED]
Subject: Policy Post 12.22: CDT and PFF Urge Courts to Rein in the FCC
(1) CDT and PFF Urge Courts to Rein in the FCC
(2) FCC's Indecency Authority Based on Archaic Assumptions
(3) Innovation Undermines FCC's Authority to Regulate Speech
(4) CDT Continues Fight for Freedom of Speech in the Digital Age
----------------------------------------
(1) CDT and PFF Urge Courts to Rein in the FCC
Last week, the Center for Democracy and Technology (CDT) and Adam
Thierer of the Progress and Freedom Foundation (PFF) filed
friend-of-the-court briefs in two federal appellate cases before the
Second and Third Circuits challenging Federal Communications Commission
(FCC) broadcast indecency rulings as threats to freedom of speech.
In recent years, the FCC has grossly expanded its regulation of
"indecent" but otherwise legal speech on television and radio. CDT and
PFF in their amicus briefs urged the courts to overturn the
Commission's rulings because they violate the First Amendment. The
groups also encouraged the courts to rein in the FCC given that
technological convergence coupled with the increased availability of
user-empowerment tools are undermining the Commission's authority to
regulate indecent speech.
The Second Circuit case concerns the FCC's conclusion that the use of
certain expletives on various TV shows was "indecent." The Third
Circuit case relates to the Commission's unprecedented ,000 fine
against CBS for Janet Jackson's infamous "wardrobe malfunction" during
the 2004 Super Bowl halftime show.
- 2nd Circuit Brief: http://www.cdt.org/speech/20061129circuit2.pdf
- 3rd Circuit Brief: http://www.cdt.org/speech/20061129circuit3.pdf
----------------------------------------
(2) FCC's Indecency Authority Based on Archaic Assumptions
The Supreme Court narrowly upheld the FCC's authority to regulate
indecent speech on television and radio in the 1978 case FCC v. Pacific
Foundation. The FCC had taken action against a radio station that aired
comedian George Carlin's "Filthy Words" monologue in which he repeated
seven expletives over and over making fun of society's attitude toward
these words. The Commission invoked a federal statute (18 U.S.C. 1464)
that makes it a crime to utter "any obscene, indecent, or profane
language by means of radio communication."
The Supreme Court held that while "indecent" but not "obscene" speech
-- i.e., speech that may be offensive but does not have prurient appeal
-- is protected by the First Amendment, the FCC may nevertheless
regulate it when delivered via broadcast without offending the
Constitution. The Court noted that the broadcast medium is uniquely
"pervasive" or "invasive" and is "uniquely accessible to children, even
those too young to read." Justice Souter later explained in Denver Area
Educational Telecommunications Consortium, Inc., v. FCC (1996) that the
FCC's regulatory authority depends on broadcast being "difficult or
impossible to control without immediate supervision."
In contrast to Pacifica, the Supreme Court held in 1996 that the
justifications for regulating broadcast do not apply to the Internet.
In Reno v. ACLU, the Court struck down the Communications Decency Act,
which, among other things, prohibited the knowing transmission of
"indecent" messages to children under 18. The Court held that Congress
did not have authority to criminalize indecent speech because "the
Internet is not as 'invasive' as radio or television."
The FCC makes indecency determinations based on what is "patently
offensive as measured by contemporary community standards for the
broadcast medium." This "community standards" approach is loosely based
on that taken in the seminal case Miller v. California (1973) that
addressed the First Amendment's application to obscenity. In that case,
the Supreme Court contemplated the use of some objective,
representative evidence of "community standards," such as a survey of
what material is actually available in a given community. However, when
technology allows families to set their own "household standards," the
legitimacy of the "community standards" approach is placed in doubt.
----------------------------------------
(3) Innovation Undermines FCC's Authority to Regulate Speech
Over the past few years, the FCC has radically expanded its enforcement
of broadcast indecency. The Commission has been particularly active in
regulating television content. Citing a claimed increase in viewer
complaints, the Commission asserts that it has a broad public mandate
to boost its enforcement efforts. Former FCC Chairman Michael Powell
publicly stated in 2004 that the agency was motivated "to sharpen [its]
enforcement blade" because of the "rise in the number of complaints at
the Commission," and that "the increase in the Commission's enforcement
efforts in this area is a direct response to the increase in public
complaints."
CDT and PFF pointed out in their amicus briefs, however, that the FCC
has manipulated and mischaracterized the complaint data. Namely, the
Commission changed its complaint counting methodology in two
significant ways, and failed to be transparent about these changes.
First, during the summer of 2003, the FCC apparently began counting
identically worded form letters and computer-generated electronic
complaints as individual complaints, rather than counting them as a
single complaint. Second, during early 2004, the FCC began counting
individual indecency complaints multiple times; thus, a single
complaint sent to multiple Commission divisions or offices is now
counted more than once. Additionally, the vast majority of television
indecency complaints received by the FCC in recent years have been
generated by a single pro-regulatory advocacy group.
CDT and PFF argued in their amicus briefs that the FCC violated the
First Amendment by utterly failing to provide any objective,
representative evidence of what is in fact "patently offensive"
according to "contemporary community standards for the broadcast
medium." Instead, the FCC essentially relies on the subjective opinion
of the five commissioners: the Commission admits to simply relying on
its own "collective experience and knowledge, developed through
constant interaction with lawmakers, courts, broadcasters, public
interest groups, and ordinary citizens." And to the extent that the FCC
looks to the asserted increase in television indecency complaints as
evidence of "community standards," CDT and PFF argued that this is
improper in light of the numbers manipulation by the Commission itself
and the fact that almost all the complaints were generated by a single
advocacy group.
CDT and PFF also encouraged the Second and Third Circuits to take
advantage of this opportunity to rein in the FCC given that
technological innovation is rapidly undermining the Commission's
constitutional authority to regulate indecent speech. The groups
pointed out that adults and children alike are increasingly accessing
video and audio content on the Internet, through cable and satellite
operators, as well as DVD and video game purchases and rentals.
"Broadcast" itself is rapidly converging with new media, such that
network programming is available via cable and satellite subscriptions,
and entire episodes of popular television shows can be watched on the
ABC, CBS, NBC and Fox websites. In this era of technological
convergence, the Reno v. ACLU hands-off approach to "indecent" speech
will increasingly apply, rather than the censoring approach narrowly
upheld in Pacifica.
Additionally, technological innovation has led to the development of
more â and more effective â user empowerment tools. The "V-Chip" has
been installed in all 13-inch or larger televisions manufactured since
2000 and allows for the blocking of broadcast content based on a
ratings system. Cable and satellite set-top boxes, personal video
recorders like TiVo, and Internet filtering software and other
"parental control" features offered by ISPs allow parents, teachers,
and other caregivers to better control what content children access. In
cases like Reno v. ACLU and United States v. Playboy Entertainment
Group, Inc. (2000), the Supreme Court strongly endorsed technology as a
viable alternative to government regulation of speech.
In light of these technological advancements, CDT and PFF urged the
Second and Third Circuits not to sanction the expansion of the FCC's
broadcast indecency regulation. As "broadcast" becomes easier and
easier to control, the FCC's constitutional authority to regulate
protected albeit indecent speech increasingly withers.
----------------------------------------
(4) CDT Continues Fight for Freedom of Speech in the Digital Age
CDT will continue to monitor FCC actions that threaten freedom of
speech, and will weigh in with administrative comments and amicus
briefs whenever appropriate. Policy makers and advocates must be
vigilant to ensure that speech continues to flourish in this age of
rapid technological innovation.
Information about CDT's and PFF's efforts in this area can be found at
<http://www.cdt.org/speech/ and http://www.pff.org/cdmf>
--
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voice: 202-637-9800
fax: 202-637-0968
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4. COMPUTER: SECURITY : EDUCATION: COLLEGE: COMPUTER: Major Breach of
Posted by: "David P. Dillard" [EMAIL PROTECTED] jwneastro
Date: Tue Dec 12, 2006 4:27 am ((PST))
COMPUTER: SECURITY :
EDUCATION: COLLEGE: COMPUTER:
Major Breach of UCLA's Computer Files
Major Breach of UCLA's Computer Files
Personal information on 800,000 students, alumni and others is exposed.
Attacks lasted a year, the school says.
By Rebecca Trounson, Times Staff Writer
December 12, 2006
Los Angeles Times
<http://www.latimes.com/news/local/
la-me-ucla12dec12,0,7111141.story?coll=la-home-headlines>
A shorter URL for the above link:
<http://tinyurl.com/y55ay2>
In what appears to be one of the largest computer security breaches ever
at an American university, one or more hackers have gained access to a
UCLA database containing personal information on about 800,000 of the
university's current and former students, faculty and staff members, among
others.
UCLA officials said the attack on a central campus database exposed
records containing the names, Social Security numbers and birth dates the
key elements of identity theft for at least some of those affected. The
attempts to break into the database began in October 2005 and ended Nov.
21, when the suspicious activity was detected and blocked, the officials
said.
In a letter scheduled to be sent today to potential victims of the breach,
acting Chancellor Norman Abrams said that although some Social Security
numbers were obtained by the hackers, the university had no evidence that
any of the information had been misused.
"We take our responsibility to safeguard personal information very
seriously," Abrams said in the letter, which was scheduled to be mailed or
e-mailed overnight to those whose records were compromised. "My primary
concern is to make sure this does not happen again" and to provide
information to try to minimize the risk of identity theft for those
affected, he said.
Abrams urged those whose records might have been accessed to monitor their
consumer credit files and consider fraud alerts and other precautions.
The UCLA incident is the latest in a series of computer security breaches
affecting private organizations, financial institutions, government
agencies and other large employers. Partly because of their tradition of
openness, universities are proving to be a favorite and often vulnerable
target, several experts in the field said Monday.
----------------------------------------
The complete article may be read at the URL above.
Sincerely,
David Dillard
Temple University
(215) 204 - 4584
[EMAIL PROTECTED]
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5. Radio station for Rs 5,000 = $Can 128.35 = U$ 111.86
Posted by: "George Lessard" [EMAIL PROTECTED] themediamentor
Date: Tue Dec 12, 2006 6:18 am ((PST))
Suitcase Radio in Rs 5000
Shubhranshu Choudhary
Suitcase radio is what they call it. Weighing only about 12 kgs and
making a hole of about only Rs 5000 in your pocket, this radio
station is being prepared by three students Kamal, Vikas and Dayal
from Haryana.
One can listen to the waves till 15 kms and none of the material used
in its manufacturing is imported. All the material was procurred from
the local markets of Ambala.
http://www.cgnet.in/Med/suitcaseradio
Pls see a similar story by Nick Nugent, former head of BBC news
Radio station for Rs 5,000
http://www.cgnet.in/Med/crnugent
Currency Converter
http://www.bankofcanada.ca/en/rates/converter.html
Rs 5000 = $Can 128.35 = U$ 111.86
--
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Via / By / Excerpted / From / Tip from / Thanks to:
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