Disinfectants cause some bacteria to thrive
Study shows how savvy some bugs are, adding to research on superbugs

LiveScience

updated 11:09 a.m. CT, Mon., Dec . 28, 2009

http://www.msnbc.msn.com/id/34610828/ns/technology_and_science-science/


To keep sickness at bay, many of us constantly wash hands and disinfect 
surfaces. But a new lab study shows one pesky bacterium eats cleansers 
for breakfast: When disinfectant was applied to lab cultures of the 
bacteria, they adapted to survive not only the disinfectant but also a 
common antibiotic.

The research team focused on Pseudomonas aeruginosa, a bacterium 
responsible for a range of infections in people with weakened immune 
systems. When the scientists added increasing amounts of disinfectant to 
P. aeruginosa cultures, the bacteria adapted to survive not only the 
disinfectant but also the antibiotic called ciprofloxacin.

Here's how: The bacteria were able to more efficiently pump out 
antimicrobial agents. The adapted bacteria also had a genetic mutation 
that allowed them to resist ciprofloxacin-type antibiotics specifically.

"In principle this means that residue from incorrectly diluted 
disinfectants left on hospital surfaces could promote the growth of 
antibiotic-resistant bacteria," said lead researcher Gerard Fleming of 
the National University of Ireland in Galway. "What is more worrying is 
that bacteria seem to be able to adapt to resist antibiotics without 
even being exposed to them."

The results, published in the January issue of the journal Microbiology, 
show just how savvy some bugs are, adding to research on superbugs — 
drug-resistant microbes that modern medicine struggles to combat.

MRSA, or methicillin-resistant Staphylococcus aureus, has become a 
deadly and growing problem in hospitals in recent years. And news out 
this week suggests the country's first case of a highly drug-resistant 
form of tuberculosis.

A major factor in the emergence of these antibiotic-resistant bacteria 
is the overuse and misuse of antibiotics, according to the Centers for 
Disease Control and Prevention. The new study suggests disinfectants may 
be part of the problem, though more research is needed to firm up the link.

"We need to investigate the effects of using more than one type of 
disinfectant on promoting antibiotic-resistant strains," Fleming said. 
"This will increase the effectiveness of both our first and second lines 
of defense against hospital-acquired infections."

Fleming also stressed the importance of studying the environmental 
factors that might promote antibiotic resistance.

URL: http://www.msnbc.msn.com/id/34610828/ns/technology_and_science-science/

-- 
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George Antunes, Political Science Dept
University of Houston; Houston, TX 77204
Voice: 713-743-3923  Fax: 713-743-3927
Mail: antunes at uh dot edu

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