memcached out of the box versus behavior tweaks

[Patrick Galbraith]

Hi all,

Just wondering about a few things while pondering - what are most people 
using in terms of memcached out of the box - starting it up with a 
particular size, but not setting any particular behavior, or what 
settings have people modified in the behavior of the client that they've 
found useful for their installations?

Also, for large installations, what have people found works better - one 
large instance or smaller multiple instances? I'm thinking if you were 
to use buckets, that the latter wouldn't be as necessary.

Thoughts?