Hi everyone

After elute the protein from Ni-NTA beads I washed the beads with 0.5M NaOH
to get rid off imadozole and traces of protein on the bead, but
unfortunately the column turns yellow colour? My recombinant protein which
fusioned to m-cherry, even after elution the column looks light pink in
colour. could anyone explain why it has happened and how I could get back
Ni-NTA beads to normal light blue color.

Thank you in advance

-- 
Sudheer Babu.S
Research Fellow
Institute of Biochemistry
Biological Research Center
Szeged,Hungary.
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