In article <mailman.36.1404234689.12244.meth...@net.bio.net>, sudheer.pb...@gmail.com says... > Glycolysis produces NADH, FADH futher these will enter into oxidative > phosphorylation followed by ATP sythesis. How much time require to get one > ATP molecule by breaking down of one glucose molecule.
You can figure this out from observable data: We consume about 11,000 L of air each day, the oxygen content of the air we inhale is 20%, of the air we exhale 15%. Thus we consume about 550 L of molecular oxygen, or about 24.6 mol (as 1 mol of an ideal gas under standard conditions has 22.4 L). Assuming for simplicity that we burned only glucose (no fat or amino acids). Given that aerobic catabolism of a mol of O2 yields about 5 mol of ATP (the exact number is still a matter of scientific debate, but let's ignore this), 123 mol of ATP () are produced from ADP (molecular mass 507 Da -> 62.3 kg). For a 80 kg human, assuming about 60% intracellular volume, and given a cellular [ATP] of 3 mM the average content would be 0.144 mol ([ADP] is 100-fold lower and therefore can be ignored in this "pi times thumb" calculation). Thus each molecule of ATP present in our body is hydrolysed to ADP and resynthesised on average about 853 times a day (24 h x 60 min x 60 s) or once every 101 seconds. This is of course an average, in metabolically highly active tissue this rate would be considerably higher. Brain for example consumes about 1/3 of our oxygen supply, therefore produces about 41 mol of ATP (note that under normal metabolic conditions brain energy supply is almost exclusively from oxidation of Glc). Brain mass is 1.5 kg, about, say, 90% intracellular volume, so 1.35 L cytosol or 4.05 mmol of ATP. Thus turnover would be 10,123 times a day or once every 8.5 s, 12 times faster than body average. _______________________________________________ Methods mailing list Methods@net.bio.net http://www.bio.net/biomail/listinfo/methods
