Hey there.
If you want to use the same codebase for multiple sites and domains,
option 3 is your best bet. You can even have different frontend themes
for each site, but all your installed apps will be the same. Each site
will have its own Admin as long as all your models inherit from
SiteRelated (which is the case for all Mezzanine apps).
If you think you're going to be using different installed apps and that
each project will require more customization, you should go with option
1. I would advise you never use option 2 because it kinda defeats the
concept of sandboxing and encapsulation provided by virtualenvs.
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