I would check your crontab to see what is running at 5AM.  This sounds more
like the box running out or ram or something.

> A couple weeks ago I opted to use the MIMEDefang embedded perl interpreter
> (by turning on MX_EMBED_PERL=yes in the MD init script), however, I have
> noticed some stability problems when using the embedded interpreter.
Every
> morning at 5am the MD multiplexor essentially craps out, requiring
> MIMEDefang, clamd, and sendmail to be restarted.  I didn't see much in the
> log files indicating what was causing the multiplexor to die off, but I do
> know that the daily CRON jobs run at around 4-5am every night.
>
> Any insight would be appreciated.

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