There was discussion about this last week. You probably set Milter timeouts in sendmail.mc (INPUT_MAIL_FILTER line) too low.
Sorry, I should have mentioned that I saw that discussion, but my problem seems to be different. I didn't see the same symptoms of the defang process being restarted quickly, for example, and there definitely seems to be a connection to this error:
Nov 22 09:33:54 kahuna mimedefang[5656]: iAMHXhdD005903: smfi_addheader returned MI_FAILURE
:j
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