Law #8 - An out of date virus scanner is only marginally better than no virus scanner at all http://www.microsoft.com/technet/archive/community/columns/security/essay s/10imlaws.mspx
Just to be contrary ;) I'll say that it depends on your objective: Viruses tend to "stay in the system" a long time and if you've got savvy users who already know to use a good MUA and who don't blindly click on things, then the benefit of AV at the mail gateway is to reduce the load of looking at the stuff. It's essentially the same benefit you get from a spam scanner.
Alas, most of us suffer clueless users and PHB's insisting on vulnerable clients (mostly made by guess-who) so MS' point is well-taken.
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