Posting this here for documentation purposes: After the 6.4 / Firefox 63.0 upgrade the ublock/umatrix addons in Firefox stopped working.
After some discussion with landry@ it turned out that the root cause is that my home folder is on NFS. This causes a pledge violation, as seen in these log records: firefox[24601]: pledge "getpw", syscall 33 The fix is to open the Firefox configuration ("about:config") and add "getpw" to the "security.sandbox.pledge.content" parameter. /Robert