Sorry for the late response.

I am currently facing an issue that OpenSMTPd disables a route for a
dual-stack MX if a connection to the v4 address fails, without retrying
v6.

The system has a local v4 network, but no routes; A v6 default route is
set and the system is reachable via IPv6.

Have you tried forcing IPv6 with a IPv6 src address at the relay action?

action "outbound" relay src $v6adr


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