I've asked this here before, but I'm hoping that there have been some changes or updates and I missed the email:

What's the state of the art in terms of configuring permissions on BLAST target files (specifically the MBF files) so that multiple users can run searches against targets in a shared directory, make use of cached index and sequence files, and not encounter the dreaded:

Error opening /common/data/nt.mbf
open: Permission denied
Fatal Error:

From perusing the list archives I see the following options:
------------------------------------------------------------------------ -------- * Make a custom BLAST target directory for every user (not enough disk space, doesn't scale)

* Hack MPIBlast code to change the file permissions on the MBF files (seems reasonable, but there must be some reason why it's not already done. Probably concerns about users stepping on each other's jobs).

* Install pre and post scripts in my DRM to erase cached files after each job is done (why have a cache at all?)

Is there another option that I'm missing here? How do folks handle this at large-ish installations with multiple users who each may run mpiblast jobs against shared targets?

-Chris Dwan

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