Nope,you can directly go with CU2 on R2.Look at Update Replacement Information 
from CU2 KB article http://support.microsoft.com/kb/2970177Update replacement 
informationThis update replaces Cumulative Update 1 for System Center 2012 R2 
Configuration Manager.
To upgrade clients to CU2 refer 
http://eskonr.com/2014/07/sccm-configmgr-2012-r2-collections-to-upgrade-clients-to-cu2-version/
Thanks,Eswar Koneti 
www.eskonr.com


> From: [email protected]
> To: [email protected]
> Date: Tue, 8 Jul 2014 08:48:55 +0100
> Subject: [mssms] SCCM 2012 R2 CU2
> 
> Is CU1 required before CU2 can be installed? I can't seem to find anything on 
> technet to clarify this.
> 
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