Here's the solution from http://support.microsoft.com/kb/2984972
Known issues with this security update Symptoms After you install this security update, virtualized applications in Microsoft Application Virtualization (App-V) versions 4.5, 4.6, and 5.0 may experience problems loading. When the problem occurs, you may receive an error message that resembles the following: Launching MyApp 100% Note In this error message, MyApp represents the name of the App-V application. Depending on the scenario, the virtualized app may stop responding after it starts, or the app may not start at all. Important This section, method, or task contains steps that tell you how to modify the registry. However, serious problems might occur if you modify the registry incorrectly. Therefore, make sure that you follow these steps carefully. For added protection, back up the registry before you modify it. Then, you can restore the registry if a problem occurs. For more information about how to back up and restore the registry, click the following article number to view the article in the Microsoft Knowledge Base: 322756 How to back up and restore the registry in Windows Resolution To resolve this known issue, configure the TermSrvReadyEvent registry entry on the computer where the Microsoft Application Virtualization Client is installed. For Microsoft Application Virtualization 5.0 Registry Key: HKLM\Software\Microsoft\AppV\Subsystem\ObjExclusions Value name: 93 (Or any unique value) Type: REG_SZ Data: TermSrvReadyEvent Example For example, type the following command at an elevated command prompt to add the entry to a system running Application Virtualization 5.0: reg add HKLM\Software\Microsoft\AppV\Subsystem\ObjExclusions /v 93 /t REG_SZ /d TermSrvReadyEvent For Microsoft Application Virtualization 4.6 For all supported x86-based systems Registry Key: HKLM\SOFTWARE\Microsoft\SoftGrid\4.5\SystemGuard\ObjExclusions Value name: 95 (Or any unique value) Type: REG_SZ Data: TermSrvReadyEvent Example For example, type the following command at an elevated command prompt to add the entry to an x86-based system running Application Virtualization 4.6: reg add HKLM\SOFTWARE\Microsoft\SoftGrid\4.5\SystemGuard\ObjExclusions /v 95 /t REG_SZ /d TermSrvReadyEvent For all supported x64-based systems Registry Key: HKLM\SOFTWARE\Wow6432Node\Microsoft\SoftGrid\4.5\SystemGuard\ObjExclusions Value name: 95 (Or any unique value) Type: REG_SZ Data: TermSrvReadyEvent Example For example, type the following command at an elevated command prompt to add the entry to an x64-based system running Application Virtualization 4.6: reg add HKLM\SOFTWARE\Wow6432Node\Microsoft\SoftGrid\4.5\SystemGuard\ObjExclusions /v 95 /t REG_SZ /d TermSrvReadyEvent -----Original Message----- From: [email protected] [mailto:[email protected]] On Behalf Of Stephen Murley Sent: 20 October 2014 19:32 To: [email protected] Subject: [mssms] RE: KB2984972 and App-V Sorry, what did you say then?? I wasn't listening. ________________________________ From: [email protected] [[email protected]] on behalf of Michael Mott [[email protected]] Sent: 20 October 2014 18:52 To: [email protected] Subject: [mssms] RE: KB2984972 and App-V So basically you don't listen. From: [email protected] [mailto:[email protected]] On Behalf Of Stephen Murley Sent: Monday, October 20, 2014 9:29 AM To: [email protected] Subject: [mssms] KB2984972 and App-V Well, I'd read the media article but still didn't believe it as it went on and on about AutoCAD in App-V. Anyhow, yes, this update does botch App-V apps. I estimate 60% of our App-V apps stop working with this update installed. ________________________________ [Image removed by sender.]<http://www.plymouth.ac.uk/worldclass> This email and any files with it are confidential and intended solely for the use of the recipient to whom it is addressed. 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