I just upgraded to 64-bit Office 365, and this solved my problem too.  But 
the new path is this one:

"C:\Program Files\Microsoft Office\root\Office16\OUTLOOK.EXE"

On Wednesday, February 8, 2012 at 5:24:26 AM UTC-7, damoski wrote:
>
> Just an observation on this error when clicking a link to an Outlook 
> email: 
>
> MyLife Organized 
> Could not execure 
> Outlook: 
> 0000000018F0380593D50248B69D794BB3ED0B8407001A61FC8DA2F4C84BB1366BDF5173127 
>
> E000000904B6B000066C999EB18F1E84684DD4CD8911C04250000049353680000 
> The operating system denied access to the specified file. 
>
>
> I was having this problem. I had upgraded from Office 2007 32-bit to 
> Office 2010 64-bit. I tried uninstalling and reinstalling MLO, as 
> recommended elsewhere, but there was no difference. I then looked at 
> the suggested registry key. 
>
> I looked at HKEY_CLASSES_ROOT\outlook\shell\open\command, and it had 
> an old DOS-format pathname.. to the old Outlook installation. ie. 
> "C:\PROGRA~2\MICROS~1\Office12\OUTLOOK.EXE" /select "%1" 
> I checked - and although the path was there, the .EXE was definitely 
> not in this location 
>
> I checked the location of my new 64-bit exe, and edited the key entry 
> to match it: 
> "C:\Program Files\Microsoft Office\Office14\outlook.exe" /select "%1" 
>
> It immediately started working. 
>
> (Andrey - does the MLO installer re-validate the Outlook.exe path and 
> file, if there's already one there? It seems it didn't in this case.) 
>

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