Anyone using TONS of Query Cache for a high-traffic site?

Our search server is really sweating.
I was about to jump through a LOT of software loops to program
query caching at the app level, when I realized that MySQL had
it built-in already.  (We're using newest: 4.0.18)

Seems we've got plenty of Qcache_free_memory (see below) - so
I'm wondering...

Has anyone set their query_cache_size= setting really high 
like 1GB of RAM - to see how it helps?

Any more articles or info on this besides the docs at
http://www.mysql.com/doc/en/Query_Cache.html ?




| Key_blocks_used          | 29625      |
| Key_read_requests        | 31993562   |
| Key_reads                | 28450      |
| Key_write_requests       | 204631     |
| Key_writes               | 131756     |
| Max_used_connections     | 140        |
| Not_flushed_key_blocks   | 0          |
| Not_flushed_delayed_rows | 0          |
| Open_tables              | 100        |
| Open_files               | 146        |
| Open_streams             | 0          |
| Opened_tables            | 106        |
| Questions                | 1337108    |
| Qcache_queries_in_cache  | 11363      |
| Qcache_inserts           | 530809     |
| Qcache_hits              | 520845     |
| Qcache_lowmem_prunes     | 0          |
| Qcache_not_cached        | 1984       |
| Qcache_free_memory       | 255088000  |
| Qcache_free_blocks       | 4773       |
| Qcache_total_blocks      | 27515      |
| Rpl_status               | NULL       |
| Select_full_join         | 1005       |
| Select_full_range_join   | 0          |
| Select_range             | 22         |
| Select_range_check       | 803        |
| Select_scan              | 6271       |
| Slave_open_temp_tables   | 0          |
| Slave_running            | ON         |
| Slow_launch_threads      | 0          |
| Slow_queries             | 138        |
| Sort_merge_passes        | 0          |
| Sort_range               | 105822     |
| Sort_rows                | 1479015    |
| Sort_scan                | 5009       |
| Table_locks_immediate    | 638173     |
| Table_locks_waited       | 5449       |
| Threads_cached           | 8          |
| Threads_created          | 4300       |
| Threads_connected        | 111        |
| Threads_running          | 2          |

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