John -

As far as serial versus USB, you will find that majority of potential users 
prefer USB (laptops, etc.).

Many of the "new Arduino style" boards have UART for serial (5-line 
implementation) with usage of USB-UART cables.
Sparkfun is one group that sells these (their version of the standard FTDI 
cable offering at $20).
https://www.sparkfun.com/products/9718?gclid=COTW15yr8McCFYQ_aQodVQAI4Q

The 18-pin daughterboard you referenced uses the FTDI FT232Rx chip (L version 
is 28-pin SSOP; Q version is 32-pin QFN)
http://www.ftdichip.com/Support/Documents/DataSheets/ICs/DS_FT232R.pdf

I like the FTDI FT-232R --- due to its ability to be programmed (invert the 
serial line, etc.).  Saves chips for those needs.

greg

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