And now:Ish <[EMAIL PROTECTED]> writes: *System Failure* - The chemical revolution has ushered in a world of changes. Many of them, it's becoming clear, are in our bodies. http://www.motherjones.com/mother_jones/JA99/endocrine.html System Failure The chemical revolution has ushered in a world of changes. Many of them, it's becoming clear are in our bodies by Jon R. Luoma July/August 1999 Elizabeth Guillette, a University of Arizona Medical anthropologist, had been hearing the stories for years. Midwives and nurses in developing countries were reporting that children growing up in areas with high levels of pesticide use were displaying problems in learning and physical skills. In order to follow up on these reports, Guillette needed to identify two populations of children that were similar in every way but one--their level of exposure to pesticides. In the torrid Yaqui Valley of Sonora, Mexico, she found what she was looking for. The Yaqui Indians of that area lived in two distinct groups: one in the valley lowlands, the other in the highland foothills. In the intensively farmed lowlands, Yaqui mothers had been exposed, over the course of numerous growing seasons, to high levels of pesticides, including compounds such as lindane and endrin, long banned for agricultural use in the United States. By contrast, foothill families lived simple ranching lives, rejecting pesticide use altogether--to the point of preferring to swat insects in the home rather than spray a pesticide. In all other respects--the most relevant being diet--the two groups lived essentially identical lives; in addition, they shared a common gene pool. They appeared to Guillette, therefore, to offer a unique chance to measure the developmental differences between groups of children who seemed to vary only in their exposure to pesticides. Her research scheme was straightforward: She adapted a series of motor and cognitive tests into simple games the children could play, including hopping, ball catching, and picture drawing. She assumed that any differences between the two groups would be subtle. Instead, she recalls, "I was shocked. I couldn't believe what was happening." The lowland children had much greater difficulty catching a ball or dropping a raisin into a bottle cap--both tests of hand-eye coordination. They showed less physical stamina too. But the most striking difference came when they were asked to draw pictures of a person. As with any group of kids, there was variation in individual skills. But most of the pictures from the foothill children looked like recognizable versions of a person. The pictures from most of the lowland children, on the other hand, were merely random lines, the kind of unintelligible scribbles a toddler might compose. Though it could take years of research to nail down precisely how the lowland children might have been harmed, it appeared likely they had suffered some kind of brain damage. Guillette based her working hypothesis--that pesticide exposure might be the cause--on her familiarity with an extensive body of animal research that had already proven that some pesticides and chemically related compounds interfere with test animals' endocrine (hormonal) systems. In both animals and humans, this system plays a critical role in nearly every aspect of development of a growing fetus--including proper formation and function of the brain and reproductive organs--and is also crucial for normal adult bodily function. In fact, Guillette's Yaqui Valley findings bolstered not only her own hypothesis, but the growing notion within the scientific community of the damage that may be caused by a class of compounds scientists call "endocrine disruptors," or EDs. These include a much broader range of chemicals than are found in pesticides, and can not only harm developing animal embryos and fetuses in dramatic ways, but can have similar impacts on human fetuses, growing children, and even adults. In the years since World War II, a veritable chemical revolution has swept the globe. Scientists in commercial and academic laboratories have synthesized some 75,000 new compounds--some 15,000 of which are currently under investigation as potential endocrine disruptors. Relatively few of these chemicals, suspected EDs or not, have received exhaustive study and testing, even as a great many have found practical applications in industrial processes and consumer products--including such presumably benign items as dental sealants, plastic toys, and plastic intravenous bags. They have, in short, become ubiquitous throughout the developed and developing worlds--meaning that it isn't just children in remote Mexican valleys exposed to pesticides banned in the United States who are at risk from these chemicals' untested and unintended effects. Experts estimate that all of us carry in our tissues some 500 compounds that simply did not exist prior to this century. Virtually all of us harbor known EDs, including polychlorinated biphenyls (PCBs), chemicals banned in the 1970s but once widely used and still persistent in the environment; and dioxins, which are byproducts of industrial processes such as chlorine bleaching. The first reports of the effects of endocrine disruptors on animals began to surface in the news media during the early 1990s. At the time, any notion that similar effects might be seen in humans (at least at the levels of contamination to which most of us are exposed) were routinely dismissed by the chemical industry and its allies as environmental fear mongering. But more recently, mounting evidence has demonstrated that humans may indeed be at serious hormonal risk. Scientists have found striking evidence of problems with male reproductive systems in the developed world, including soaring rates of testicular cancer and plummeting sperm counts, and many attribute this to hormonal disruption in the developing fetus. A scattering of studies, including Guillette's, have shown clear evidence of neurological problems in children whose pregnant mothers were exposed to EDs. Recent experiments with mice indicate that, with some compounds, damage to gonads and abnormal behavior among a mother's offspring can occur even if she is exposed to amounts so tiny that she shows no effects whatever. Other recent animal studies have supported the hypothesized link between neurological problems and contaminants that disrupt the activity of the thyroid gland, which plays a role in normal brain function.<<<END EXCERPT Reprinted under the Fair Use http://www4.law.cornell.edu/uscode/17/107.html doctrine of international copyright law. &&&&&&&&&&&&&&&&&&&&&&&&&& Tsonkwadiyonrat (We are ONE Spirit) Unenh onhwa' Awayaton http://www.tdi.net/ishgooda/ UPDATES: CAMP JUSTICE http://shell.webbernet.net/~ishgooda/oglala/ &&&&&&&&&&&&&&&&&&&&&&&&&&