> The position I have now, which appears to be workable, is to use the acnv2601 
> which will stand of Viorm of over 2.2kV.  To do a straight highspeed, 
> bidirectional interface I can use 8 (!!!) for i2c, 4 for SPI but 2 connecting 
> using UARTs should work and only need 2 optos. Ok, the device I want to talk 
> to is still i2c but I can reform the i2c conversation using a 8pin 
> microcontroller.

That's probably the way to go.  There are I2C optos, like this IXYS/Clare part:

http://www.clare.com/home/pdfs.nsf/www/CPC5902.pdf/$file/CPC5902.pdf

But, like the others, it doesn't hold off enough voltage.  There are things 
like the OPI1268 that hold off more voltage, but the Avago part is probably in 
the sweet spot.

- John

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