What voltage are you starting from, and what voltage do you want to achieve 
? Those are critical parameters for selecting a transformer and designing 
the converter circuit.

My first nixie clocks have *no* transformer, and use a voltage-doubler. 
Simple & easy to design. Just be careful about live voltages.
I've also done a tiny DC-DC converter for a wristwatch, and that was a lot 
of design and debug work.
A good middle-ground if you are doing a custom design is to use a 
power-transformer with dual primary windings, then use one of the primaries 
for your HV supply.

In the US, the 120V line-voltage will produce +170V when rectified & 
filtered. This is a bit low for reliable nixie firing over the lifetime of 
the tube, especially if you use a dropping resistor instead of a 
constant-current driver. Using a secondary winding you can 'boost' the HV a 
bit more, or you can use a voltage-doubler though the latter will waste 
more energy.


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