If you drive your tubes with a current-regulator, there's really no need to 
regulate the HV supply unless you are trying to minimize the power. All you 
need is to ensure the voltage is high enough for ionization.

I've used current-regulated cathode drivers on two of my clock designs. My 
present clock project uses a current-regulator on the anode side (each tube 
has it's own PMOS device). The drive current is adjustable with a single 
pot; I didn't see a need to tweak each tube's current independently, though 
that is possible by swapping a resistor in the current-regulator.

I've chosen current regulation instead of voltage regulation because the 
brightness and 'wearout' of the tube is a function of the current. Nixies 
have nonlinear I-V characteristics, and I've seen considerable variations 
between tubes. All of this matters when you use a constant voltage + series 
anode resistor to run the tube because you have to calculate the resistor 
value based on min & max supply voltage, min & max tube-voltage, etc. It's 
moot with a current-regulated driver.

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