Something to be aware-of is the elevated current used in multiplexing, in 
this case 10mA vs nominal 2.5mA.  Info I've read says nixie-degradation is 
an exponential function of drive-current (somewhere I saw 2.5).

Even if the exponent is 2.0, increasing the current 4X and multiplexing at 
50% would cause tubes to degrade about 8 times faster than they would with 
direct-drive. For this reason, and others, I always use direct-drive for 
discrete tubes. The one panaplex design I did had separate pins for all 
anodes & cathodes, and that, too, was direct-drive. (most multi-digit, and 
probably all dot-matrix displays require multiplexing due to pinout).

In this particular case, where only 1 tube failed, it's more likely to be a 
manufacturing defect, or the tube had substantially more hours of usage 
than the others.

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