I've used both methods with no problems, though in all cases it was 
direct-drive (non-multiplexed).

If you use a NPN cathode driver, it's easy to implement current-regulation 
with an emitter resistor. The nice thing about NPN's is that they can be 
driven by low-voltage I/O. Not just 3.3V, but even lower. The base-current 
is on the order of 200uA, so even wimpy I/Os can drive them.

If you use a NMOS cathode driver, you can still implement 
current-regulation, but you will want higher gate-drive-voltage to 
swamp-out uncertainty due to variations in Vgs(on). I use 10-12V. 
Drive-current is essentially zero.

If you use a HV5530 (or similar) and want to regulate the current, you will 
need to do that at the anode-side. My latest clock (fourteen IN-18 tubes) 
does this. Each tube requires it's own regulator; cheap insurance for 
expensive tubes.

Only my first clock design used a resistor to limit tube current. It's 
worked well over the years, but being paranoid about tube characteristics 
changing over time due to aging, I now use current-regulators. It's 
probably overkill, but I enjoy analog design work. My dying wish is to see 
my nixie clocks outlive me, and I hope to be around another 40-ish years.

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