Regarding SPICE simulators, I use 2.

For initial design work, I use LTspice. Not just because it has an 
integrated GUI environment for schematic-capture & waveforms, but also 
because it has good models for the Linear Tech devices. My only gripe is 
that it's not available on Linux.

For PCB simulation, I use ngspice. I extract netlists from my PCB 
schematics in spice format so I can run analog simulations on everything 
non-digital, including my cabling. I have found and fixed several design 
errors on 6 projects over the years. None of those PCBs has an error or 
blue-wire; PCB is right-first-time. The one PCB I did not fully simulate 
has a stupid wiring error to the DCDC converters. Go figure.

BTW, digital simulations are done on everything, even transformers and 
nixie tubes. I use Modelsim. Yes, you can crudely model a transformer in a 
digital simulator.

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