I'm doubtful that latch-up is happening here, because it usually results in 
a short-circuit across the supply. Also, the problem as described happens 
after a few hours of operation, and not during power-up. I'm suspecting a 
hold-time marginality.

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>From my experience in chip design, latch-up is initiated when excess 
current is forced thru a pin. For most IC's, the only way to do this is by 
applying a voltage greater than Vcc or less than GND (ie, a negative 
voltage) to a signal pin. Usually, currents well-above 100mA are required 
to induce latch-up; not many datasheets spec the latch-up current, but you 
can use the short-circuit current as a guideline for your design. Latch-up 
can happen on input, output, and inout pins under the right circumstances.

So, what can you do to prevent latch-up ? The highest-risk areas are 
mixed-voltage designs, where the supplies are not sequenced in a specific 
manner. If you have a +5V and +3.3V design, a diode forward-biased from the 
3.3V supply to the 5V supply will provide a lot of protection as long as 
the 3.3V supply is brought-up first, and brought-down last. Also, the 3.3V 
supply must be able to provide sufficient current to hold-up the 5V rail 
until that supply comes up. Years ago we used this on desktop PCs that had 
a mix of 3.3V and 5.0V devices; we also had a string of 3 diodes from the 
5V supply to the 3.3V supply, and that allowed supplies to come-up in any 
order. There were millions of PCs built with this approach back in the 90's 
and I'm not aware of any field returns root-caused to latch-up.

If that wont work, you can add series resistors on signals between power 
domains to limit the current. Suppose you need to protect signals between 
3.3V and 5V domains, and the current needs to be limited to 25mA (the 
output short-circuit current of an LM348 OP-amp). Be aware it takes at 
least a 'diode-drop' voltage difference (about 0.7V) to start forcing more 
current thru a CMOS pin. Knowing this, the series resistance should be at 
least R= (5 - 3.3 - 0.7)/25mA, or 40 ohms. This will affect circuit timing 
somewhat; if load-capacitance is around 25pF the signal-delay from the 
RC-network will be around 1 time-constant, which is 40*25 = 1000psec 
(1nsec) in this case. This assumes a 2.0V threshold for a 3.3V supply.

Here is a brief paper from TI that discusses latch-up: 
http://www.ti.com/lit/wp/scaa124/scaa124.pdf

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