It's like asking an audiophile if they prefer amplifiers that use tubes vs 
MOSFETs vs bipolar transistors.
You will see compelling reasons for any choice

That said, my preferences:

For true nixies (individual cathode for each numeral) HV5530 with an 
anode-current regulator
For segmented nixies like b7971, use a shift register such as 74xx595 to 
control high-voltage  NPN current-regulators on each segment.


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