The difference is either in the overall design of the output driver, and 
they are specifically designed to handle a max voltage, or they are 
bin-split during final test depending upon measurements.
Without knowing the device construction (bipolar vs NMOS) it's hard to know 
if you can push the envelope, so play it safe and stay within spec limits.

If your anode voltage is below 220 volts, the HV5522 should suffice.

I  used the HV5530 with an anode supply of +200V, just for extra margin on 
my IN-18 clock.


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