Some other useful tips I can pass along:

1. Make sure you have all of the unique parts so you can visualize how they 
will fit together. This is especially true for connectors, switches, pots, 
heat-sinked devices. Mechanical drawings in the datasheet are very helpful, 
but nothing beats having the part in your hands.

2. When you make your footprints, print them out 1:1 scale and make sure 
they match your parts. I've found a few errors this way before sending a 
board out for fab, and as a result every PCB I've made accommodated the 
parts the first time.

3. Be careful about pin diameters; it's very easy to make PCB holes too 
small for the device. I use a digital caliper to measure pin diameters. 
Also be aware that PCB manufacturers have specific drill-sizes, and the 
hole-plating process makes the holes slightly smaller. A good PCB house 
will provide specs on their hole tolerances.

4. Dont forget to add mounting holes. I usually lay those down first, 
because they block traces.

5. Dont go with minimum tracewidth/separation over the entire board. The 
tightest pad-pitch I've dealt with is 0.5mm, which is about 10 mils. Most 
PCB houses are doing 6-8mils.

6. Be aware that PCB traces are not perfect conductors. There is a handy 
tool (Saturn) available for free download that helps you understand 
resistance/voltage-drop, spacing for higher voltages, etc.

7. Dont be afraid of surface-mount devices. 0805 size components are very 
cheap and take up minimal board area. They are easy to solder by hand with 
a pair of tweezers

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