Switching the anodes is what multiplexing does, the advantage being that 
you can share the cathode logic across several tubes. But with savings, 
there is also a hidden cost: You must run the anode current higher for 
multiplexed operation versus direct-drive. If the tube is specifically 
designed to support higher peak-current for multiplexing, then there's 
minimal risk; I recall some Burroughs tubes state in the datasheet not to 
use multiplexing.

I've done a number of clock designs, all of them direct-drive. Cost is a 
secondary concern; maximizing the life of the almost- irreplaceable nixie 
tube is the overriding goal. With direct-drive, you dont need to switch the 
anode. However, I have some designs that use anode current-regulators which 
is basically a switch that is not fully-on.

Ghosting only occurs with a muliplexed display, so if you are concerned 
about it, be sure that your design has programmable blanking-time, 
refresh-rate, and on-time. You will have to experiment to get the best 
results.

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