Fundamentally, it should work, but be aware you are now pulsing the 
displays. Some folks in this group have reported audible noise from 
multiplexing. Some panaplex displays require multiplexing by the nature of 
their pinout (common cathodes, separate anodes) so that would be a moot 
issue. Instead, you would adjust the duty-cycle of your multiplexing scheme.

Another option is to reduce the anode voltage under software control; how 
that is done depends upon the type of supply you have. If you are using a 
DCDC converter, you would change the resistance value in the feedback loop.

I wouldn't worry too much about the generated heat as long as your case 
allows the heat to escape via natural convection; you dont need a fan. Your 
display will consume 4W peak, and for a clock it's probably around 2W 
average. Given the large surface area, and black color, it's going to 
radiate heat efficiently which minimizes the temperature increase. I've 
checked nixie tubes with a handheld IR thermometer, and the measured 
temperature is on-par with what I would guess by touching it. I dont think 
I've ever measured above 40 C, and that's well-within the datasheet spec of 
70C ambient temp.

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