Lung treatment could ease swine flu

http://www.google.com/hostednews/ukpress/article/ALeqM5hGDzXPi841FuE39_lbyvBsemxVDw

Patients with swine flu who experience severe respiratory failure 
should be given a specialist lung treatment, researchers have said.

The treatment - which helped pregnant woman Sharon Pentleton - saves 
one extra life for every six patients compared with conventional 
treatment for those who are critically ill.

The Glenfield Hospital in Leicester has the only adult unit in the UK 
which offers the treatment, called extracorporeal membrane 
oxygenation (ECMO).

It involves circulating the patient's blood outside the body and 
adding oxygen to it artificially.

The Glenfield Hospital has five ECMO beds and treats around 100 
patients a year on average. The unit can be expanded to 10 beds if 
necessary.

Ms Pentleton had to be flown to University Hospital in Stockholm for 
the treatment in July because the Leicester unit was full. She was 
successfully treated and has returned to her Scottish home.

The research, published in The Lancet medical journal, said patients 
with severe but potentially reversible respiratory failure should be 
treated with ECMO to "significantly improve survival without severe 
disability".

Last week, the Government's chief medical officer Sir Liam Donaldson 
said opinion on the treatment's value for adult patients was 
"divided".

He said 13 nurses were required to run one ECMO bed, compared with 
six or seven for a normal intensive care bed.

Now, University Hospitals Leicester NHS Trust said it expected ECMO 
to be an "essential weapon" in the resurgence of swine flu this 
winter.


Machine for Breathing Troubles May Aid in Swine Flu Care, Researchers Say
<'"http://www.nytimes.com/adx/bin/adx_click.html?type=goto&opzn&page=www.nytimes.com/yr/mo/day/health/research&pos=Frame4A&sn2=41866d15/6de66a27&sn1=a62f4d1e/1ca193f5&camp=foxsearch2009_emailtools_1011077c_nyt5&ad=WhipIt_b_120x60&goto=http://www.foxsearchl>
By 
<http://topics.nytimes.com/top/reference/timestopics/people/m/donald_g_jr_mcneil/index.html?inline=nyt-per>DONALD
 
G. McNEIL Jr.

http://www.nytimes.com/2009/09/16/health/research/16flu.html?_r=1

In a study with implications 
for 
<http://topics.nytimes.com/top/reference/timestopics/subjects/i/influenza/swine_influenza/index.html?inline=nyt-classifier>swine
 
flu treatment, British researchers have found that some patients with 
severe breathing problems do better if their blood is run through a 
heart-lung machine than if they are attached to a conventional 
ventilator.

If swine flu hospitalizations increase rapidly as the winter gets 
colder, pressure could rise to put the sickest patients on such 
machines, which oxygenate the blood without forcing air into the 
lungs, giving lung tissue the chance to rest and heal. Only 80 to 
100 
<http://topics.nytimes.com/top/news/health/diseasesconditionsandhealthtopics/hospitals/index.html?inline=nyt-classifier>hospitals
 in 
the United States have them - though that is far more than in 
Britain, where resources were heavily taxed even in its relatively 
small 
<http://health.nytimes.com/health/guides/disease/the-flu/overview.html?inline=nyt-classifier>flu
 outbreak 
last spring.

"We have already used ECMO during the first wave of the pandemic with 
good effect, and we are expecting ECMO to prove an invaluable weapon 
in the fight against the winter resurgence of the infection," said 
one of the study's authors, Dr. Giles Peek, at Glenfield Hospital in 
Leicester, England, using the shorthand for the official name for the 
therapy, extracorporeal membrane oxygenation.

The study was published online Tuesday 
in <http://www.thelancet.com/>The Lancet.

The technology, a smaller version of the heart-lung machine used in 
open-heart surgery, has been around since the 1980s and has saved the 
lives of thousands of premature infants with underdeveloped lungs, 
said Dr. Joseph B. Zwischenberger, an ECMO expert and a chest surgeon 
at the medical school at 
the 
<http://topics.nytimes.com/top/reference/timestopics/organizations/u/university_of_kentucky/index.html?inline=nyt-org>University
 
of Kentucky, who wrote a commentary on the study for The Lancet.

Dr. Zwischenberger said the effects of the technology were "dramatic" 
in newborns and satisfactory in children, adding, "How it does in 
adults depends on how carefully they're selected."

He said young flu patients with previously healthy lungs would be 
ideal candidates.

The British study, which took eight years and screened 766 patient to 
find two groups of 90 to undergo competing treatments, found that 
ECMO gave adults a 16 percent better chance of survival. The study, 
paid for by Britain's national health service, originally had nothing 
to do with swine flu and was created to help national health 
officials judge whether the benefits of the expensive technology 
outweighed its risks enough to justify the cost.

"If you're a glass-half-full kind of guy, you'd say 16 percent is 
great," Dr. Zwischenberger said. "If you're a glass-half-empty kind 
of guy, you'd say, 'Why should I take the risk of moving my patient 
to another hospital when I could tweak my ventilator care to maybe 
get that 16 percent?' "

The machine itself, which runs the blood through microfibers that let 
oxygen in and carbon dioxide out, is not much more expensive than a 
good ventilator; it can cost up to $50,000, while sophisticated 
ventilators can run about $35,000.

But because the blood must be thinned, creating a constant danger of 
hemorrhaging or clots, it requires far closer monitoring: one 
therapist per one or two patients 24 hours a day, while a respiratory 
technician can monitor up to 10 patients on ventilators and a nurse 
can watch up to 4, Dr. Zwischenberger estimated.

Vaccine Is Approved

WASHINGTON (AP) - 
The 
<http://topics.nytimes.com/top/reference/timestopics/organizations/f/food_and_drug_administration/index.html?inline=nyt-org>Food
 
and Drug Administration approved the new swine flu vaccine, a 
long-anticipated step as the government works to start 
mass 
<http://health.nytimes.com/health/guides/specialtopic/immunizations-general-overview/overview.html?inline=nyt-classifier>vaccinations
 next 
month. Limited supplies should start trickling out the first week of 
October
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