*Dr. John Campbell explains the benefits of Vitamin D against COVID-19, * *so that laypeople can understand them: https://www.youtube.com/watch?v=i0krPqSaBPI <https://www.youtube.com/watch?v=i0krPqSaBPI>* *(His observations on Vitamin D deficiency among black and Hispanic* *people in the US—populations especially hard-hit by this coronavirus—are * *especially noteworthy.) *
*NIH study:* Vitamin D and the Immune System Cynthia Aranow <https://www.ncbi.nlm.nih.gov/pubmed/?term=Aranow%20C%5BAuthor%5D&cauthor=true&cauthor_uid=21527855>, MD, Investigator https://www.ncbi.nlm.nih.gov/pubmed/21527855 Author information <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166406/#> Copyright and License information <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166406/#> Disclaimer <https://www.ncbi.nlm.nih.gov/pmc/about/disclaimer/> The publisher's final edited version of this article is available at J Investig Med <https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=21527855> See other articles in PMC that cite <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166406/citedby/> the published article. Go to: <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166406/#> Abstract The Possible Role of Vitamin D in Suppressing Cytokine Storm and Associated Mortality in COVID-19 Patients Ali Daneshkhah, Vasundhara Agrawal, Adam Eshein, Hariharan Subramanian, Hemant Kumar Roy, Vadim Backman *https://www.medrxiv.org/content/10.1101/2020.04.08.20058578v3* <https://www.medrxiv.org/content/10.1101/2020.04.08.20058578v3> This article is a preprint and has not been peer-reviewed. It reports new medical research that has yet to be evaluated and so should *not* be used to guide clinical practice. <https://www.medrxiv.org/content/what-unrefereed-preprint> - Abstract <https://www.medrxiv.org/content/10.1101/2020.04.08.20058578v3> - Info/History <https://www.medrxiv.org/content/10.1101/2020.04.08.20058578v3.article-info> - Metrics <https://www.medrxiv.org/content/10.1101/2020.04.08.20058578v3.article-metrics> - - - Preview PDF <https://www.medrxiv.org/content/10.1101/2020.04.08.20058578v3.full.pdf+html> Abstract Abstract Background Large-scale data show that the mortality of COVID-19 varies dramatically across populations, although the cause of these disparities is not well understood. In this study we investigated whether severe COVID-19 is linked to Vitamin D (Vit D) deficiency. Method Daily admission, recovery and deceased rate data for patients with COVID-19 from countries with a large number of confirmed patients (Germany, South Korea (S. Korea), China (Hubei), Switzerland, Iran, UK, US, France, Spain, Italy) as of April 20, 2020 were used. The time-adjusted case mortality ratio (T-CMR) was estimated as the number of deceased patients on day N divided by the number of confirmed cases on day N-8. The adaptive average of T-CMR (A-CMR) was further calculated as a metric of COVID-19 associated mortality in different countries. Although data on Vit D level is not currently available for COVID-19 patients, we leveraged the previously established links between Vit D and C-Reactive Protein (CRP) and between CRP and severe COVID-19, respectively, to estimate the potential impact of Vit D on the reduction of severe COVID-19. Findings A link between Vit D status and COVID-19 A-CMR in the US, France, and the UK (countries with similar screening status) may exist. Combining COVID-19 patient data and prior work on Vit D and CRP levels, we show that the risk of severe COVID-19 cases among patients with severe Vit D deficiency is 17.3% while the equivalent figure for patients with normal Vit D levels is 14.6% (a reduction of 15.6%). Interpretation Given that CRP is a surrogate marker for severe COVID-19 and is associated with Vit D deficiency, our finding suggests that Vit D may reduce COVID-19 severity by suppressing cytokine storm in COVID-19 patients. Further research is needed to account for other factors through direct measurement of Vit D levels. -- If you appreciate News From Underground, please consider making a donation — either a one-time gift or a monthly subscription: http://markcrispinmiller.com/support/ Thank you for your support. Ways to unsubscribe: 1) send a blank email to [email protected] PLEASE NOTE: you must unsubscribe using the SAME email with which you subscribed 2) go to http://groups.google.com/group/newsfromunderground and click on the "Unsubscribe or change membership" link in the yellow bar at the top of the page, then click the "Unsubscribe" button on the next page. For more News From Underground, visit http://markcrispinmiller.com --- You received this message because you are subscribed to the Google Groups "News From Underground" group. To unsubscribe from this group and stop receiving emails from it, send an email to [email protected]. To view this discussion on the web visit https://groups.google.com/d/msgid/newsfromunderground/CAGxB6W_x2_6UsQDbK_hOppcv5gs79LXjAYou1BmRV1z0qT4XZA%40mail.gmail.com.
