*If they get the go-ahead to test colchicine on COVID patients, and it
works,*
*don't expect "our free press" to report it.*


*MCM*

Hadassah doctors crack the cause of fatal corona blood clotsHadassah
researchers discovered that patients who form fatal blood clots have an
increased level of alpha defensin protein in their blood.
By MAAYAN JAFFE-HOFFMAN <https://www.jpost.com/author/maayan-jaffe-hoffman>

JUNE 16, 2020 18:31
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[image: Red blood cells (illustrative) (photo credit: Wikimedia Commons)]
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A research team at Hadassah-University Medical Center in Jerusalem’s Ein
Kerem has discovered what they believe causes coronavirus
<https://www.jpost.com/coronavirus> patients to become seriously ill and
even die. They also say they have a way to treat the cause before it’s too
late.
At least 30% of patients with coronavirus develop blood clots that block
the flow of blood to their kidneys, heart and brain, as well as the lungs,
according to international research.
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Hadassah researchers discovered that the patients who form these fatal
clots have an increased level of alpha defensin protein in their blood,
explained Dr. Abd Alrauf Higavi, who directs a lab at Hadassah and has been
studying blood clots for 30 years.
“Patients with mild symptoms have a low concentration of alpha defensin,”
he said. “Patients with strong disease symptoms have high levels. The
people who die have very high levels.”
The Hadassah team studied more than 700 blood samples from 80 patients who
were admitted to the medical center during the first peak of the
coronavirus outbreak in Israel. The results show that alpha defensin speeds
up blood clot formation, which can cause pulmonary embolism, heart attacks
and stroke. In addition, when blood clots form in the alveoli, whose
function it is to exchange oxygen and carbon dioxide molecules to and from
the bloodstream, this can lead to respiratory distress and eventually
intubation.
Multiple studies have shown that around 80% of coronavirus patients who are
intubated have died.
*Higavi said his team are en route to a solution: administering the drug
colchicine to coronavirus patients.*

Colchicine is an approved drug used in the prevention and treatment of gout
attacks, caused by too much uric acid in the blood.
Higavi said they have completed testing colchicine on mice and found that
it successfully inhibited the release of alpha defensin. Now, they are
waiting for the necessary approvals to test it on human coronavirus
patients.

*Click on the link for the rest*

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