Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients
- Alexey Polonikov* - - *https://pubs.acs.org/doi/10.1021/acsinfecdis.0c00288 <https://pubs.acs.org/doi/10.1021/acsinfecdis.0c00288> * Cite this: <https://pubs.acs.org/action/showCitFormats?doi=10.1021%2Facsinfecdis.0c00288&href=/doi/10.1021%2Facsinfecdis.0c00288>*ACS Infect. Dis.* 2020, 6, 7, 1558–1562 Publication Date:May 28, 2020 <https://pubs.acs.org/doi/10.1021/acsinfecdis.0c00288#> https://doi.org/10.1021/acsinfecdis.0c00288 Copyright © 2020 American Chemical Society RIGHTS & PERMISSIONS <https://pubs.acs.org/page/rightslinkno.jsp> [image: Authors Choice]ACS AuthorChoice <https://pubs.acs.org/page/policy/authorchoice_termsofuse.html> Article Views 78375 Altmetric 577 Citations 3 <https://pubs.acs.org/doi/10.1021/acsinfecdis.0c00288#citeThis> LEARN ABOUT THESE METRICS <https://pubs.acs.org/doi/10.1021/acsinfecdis.0c00288#> PDF (2 MB) <https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.0c00288> SUBJECTS: - Nutrition <https://pubs.acs.org/action/doSearch?ConceptID=292101>, - Infectious diseases <https://pubs.acs.org/action/doSearch?ConceptID=291430>, - Organic compounds <https://pubs.acs.org/action/doSearch?ConceptID=292178>, - [image: Go to Volume 6, Issue 7] <https://pubs.acs.org/toc/aidcbc/6/7> ACS Infectious Diseases <https://pubs.acs.org/acsinfectious> Abstract Higher rates of serious illness and death from coronavirus SARS-CoV-2 (COVID-19) infection among older people and those who have comorbidities suggest that age- and disease-related biological processes make such individuals more sensitive to environmental stress factors including infectious agents like coronavirus SARS-CoV-2. Specifically, impaired redox homeostasis and associated oxidative stress appear to be important biological processes that may account for increased individual susceptibility to diverse environmental insults. The aim of this Viewpoint is to justify (1) the crucial roles of glutathione in determining individual responsiveness to COVID-19 infection and disease pathogenesis and (2) the feasibility of using glutathione as a means for the treatment and prevention of COVID-19 illness. The hypothesis that glutathione deficiency is the most plausible explanation for serious manifestation and death in COVID-19 patients was proposed on the basis of an exhaustive literature analysis and observations. The hypothesis unravels the mysteries of epidemiological data on the risk factors determining serious manifestations of COVID-19 infection and the high risk of death and opens real opportunities for effective treatment and prevention of the disease. *Click on the link for the rest.* -- If you appreciate News From Underground, please consider making a donation — either a one-time gift or a monthly subscription: http://markcrispinmiller.com/support/ Thank you for your support. Ways to unsubscribe: 1) send a blank email to [email protected] PLEASE NOTE: you must unsubscribe using the SAME email with which you subscribed 2) go to http://groups.google.com/group/newsfromunderground and click on the "Unsubscribe or change membership" link in the yellow bar at the top of the page, then click the "Unsubscribe" button on the next page. For more News From Underground, visit http://markcrispinmiller.com --- You received this message because you are subscribed to the Google Groups "News From Underground" group. To unsubscribe from this group and stop receiving emails from it, send an email to [email protected]. To view this discussion on the web visit https://groups.google.com/d/msgid/newsfromunderground/CAGxB6W-4jw-c6%3DR_baBhF2WS-tZpGN6QxUki1b9RC%3D7MJWZMLQ%40mail.gmail.com.
