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THE CORONAVIRUS CRISIS
<https://www.npr.org/series/812054919/the-coronavirus-crisis>
U.K. Preparing COVID-19 Vaccine Trials That Deliberately Expose Study
Subjects

   -

October 20, 20208:40 AM ET

https://www.npr.org/sections/coronavirus-live-updates/2020/10/20/925723045/u-k-preparing-covid-19-vaccine-trials-that-deliberately-infect-study-subjects

SCOTT NEUMAN <https://www.npr.org/people/131724812/scott-neuman>
Twitter <https://www.twitter.com/ScottNeumanNPR>

The study is still awaiting final regulatory approval. If given the green
light, a study in which human volunteers will be infected with the
coronavirus will begin in January at a biosecure unit at London's Royal
Free Hospital.
Kirsty O'Connor/PA Images via Getty Images

Updated at 9:00 a.m. ET

Researchers in Britain are preparing to start a controversial COVID-19
"human challenge" study in which dozens of healthy volunteers will be
exposed to live coronavirus in an effort to speed up vaccine development.

The Human Challenge Programme will be conducted by Imperial College London,
which said Tuesday in a statement
<https://www.imperial.ac.uk/news/206893/uk-researchers-explore-human-challenge-studies/>
that
it would be working in cooperation with the Department for Business, Energy
and Industrial Strategy, the Royal Free London NHS Foundation Trust
<https://www.royalfree.nhs.uk/>, and hVIVO
<https://hvivo.com/the-human-challenge-programme/>, a clinical company that
has worked on viral human challenge models.

The U.K. government is preparing to invest $43.4 million (33.6 million
pounds) in the study, which is the first of its kind involving the
coronavirus.

The plan is to recruit healthy people between the ages of 18 and 30 with no
prior history of COVID-19 symptoms and no known risk factors for the
disease. Researchers would inoculate them with a candidate vaccine, then
test its effectiveness by deliberately exposing them to live coronavirus.

The study is still awaiting final regulatory approval. If it is given the
green light, it will begin in January at a biosecure unit at London's Royal
Free Hospital. Volunteers will be quarantined in the facility and receive a
laboratory-grown SARS-CoV-2 strain as part of the trial. They will be
monitored around the clock for a few weeks.
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