An Australian girl spontaneously switched blood groups and adopted her
donor's immune system following a liver transplant in the first known
case of its type, doctors treating her said Thursday.




Demi-Lee Brennan was aged nine and seriously ill with liver failure when she 
received the transplant, doctors at a top Sydney children's hospital told AFP.


Nine months later it was discovered that she had changed blood types
and her immune system had switched over to that of the donor after stem
cells from the new liver migrated to her bone marrow.


She is now a healthy 15-year-old, Michael Stormon, a hepatologist
treating her, told AFP. Stormon said he had given several presentations
on the case around the world and had heard of none like it.


"It is extremely unusual -- in fact we don't know of any other instance
in which this happened," Stormon told AFP from the Children's Hospital.



"In effect she had had a bone marrow transplant. The majority of her 
immune system had also switched over to that of the donor."



An article on the case was published in Thursday's edition of the leading US 
medical journal The New England Journal of Medicine.


Doctors who treated Brennan say she is now only under treatment as an
outpatient and are interested to know if the case could have other
applications in transplant surgery, where rejection of donor organs by
the recipient's immune system is a major hurdle.


Stormon said it appeared that Brennan may have been fortunate because a
"sequence of serendipitous events", including a post-transplantation
infection, may have given the stem cells from her donor's liver the
chance to proliferate.



The task now was to establish whether the same sort of outcome could be 
replicated in other transplant patients, he said.

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