Interesting essay in Wired that is at least worth thinking about...

http://www.wired.com/print/science/discoveries/magazine/16-07/pb_theory/

WIRED MAGAZINE: 16.07
By Chris Anderson 06.23.08

Essay: The Data Deluge Makes the Scientific Method Obsolete

"All models are wrong, but some are useful."

So proclaimed statistician George Box 30 years ago, and he was right.
But what choice did we have? Only models, from cosmological equations
to theories of human behavior, seemed to be able to consistently, if
imperfectly, explain the world around us. Until now. Today companies
like Google, which have grown up in an era of massively abundant data,
don't have to settle for wrong models. Indeed, they don't have to
settle for models at all.

Sixty years ago, digital computers made information readable. Twenty
years ago, the Internet made it reachable. Ten years ago, the first
search engine crawlers made it a single database. Now Google and
like-minded companies are sifting through the most measured age in
history, treating this massive corpus as a laboratory of the human
condition. They are the children of the Petabyte Age.

The Petabyte Age is different because more is different. Kilobytes
were stored on floppy disks. Megabytes were stored on hard disks.
Terabytes were stored in disk arrays. Petabytes are stored in the
cloud. As we moved along that progression, we went from the folder
analogy to the file cabinet analogy to the library analogy to — well,
at petabytes we ran out of organizational analogies.

At the petabyte scale, information is not a matter of simple three-
and four-dimensional taxonomy and order but of dimensionally agnostic
statistics. It calls for an entirely different approach, one that
requires us to lose the tether of data as something that can be
visualized in its totality. It forces us to view data mathematically
first and establish a context for it later. For instance, Google
conquered the advertising world with nothing more than applied
mathematics. It didn't pretend to know anything about the culture and
conventions of advertising — it just assumed that better data, with
better analytical tools, would win the day. And Google was right.

Google's founding philosophy is that we don't know why this page is
better than that one: If the statistics of incoming links say it is,
that's good enough. No semantic or causal analysis is required. That's
why Google can translate languages without actually "knowing" them
(given equal corpus data, Google can translate Klingon into Farsi as
easily as it can translate French into German). And why it can match
ads to content without any knowledge or assumptions about the ads or
the content.

Speaking at the O'Reilly Emerging Technology Conference this past
March, Peter Norvig, Google's research director, offered an update to
George Box's maxim: "All models are wrong, and increasingly you can
succeed without them."

This is a world where massive amounts of data and applied mathematics
replace every other tool that might be brought to bear. Out with every
theory of human behavior, from linguistics to sociology. Forget
taxonomy, ontology, and psychology. Who knows why people do what they
do? The point is they do it, and we can track and measure it with
unprecedented fidelity. With enough data, the numbers speak for
themselves.

The big target here isn't advertising, though. It's science. The
scientific method is built around testable hypotheses. These models,
for the most part, are systems visualized in the minds of scientists.
The models are then tested, and experiments confirm or falsify
theoretical models of how the world works. This is the way science has
worked for hundreds of years.

Scientists are trained to recognize that correlation is not causation,
that no conclusions should be drawn simply on the basis of correlation
between X and Y (it could just be a coincidence). Instead, you must
understand the underlying mechanisms that connect the two. Once you
have a model, you can connect the data sets with confidence. Data
without a model is just noise.

But faced with massive data, this approach to science — hypothesize,
model, test — is becoming obsolete. Consider physics: Newtonian models
were crude approximations of the truth (wrong at the atomic level, but
still useful). A hundred years ago, statistically based quantum
mechanics offered a better picture — but quantum mechanics is yet
another model, and as such it, too, is flawed, no doubt a caricature
of a more complex underlying reality. The reason physics has drifted
into theoretical speculation about n-dimensional grand unified models
over the past few decades (the "beautiful story" phase of a discipline
starved of data) is that we don't know how to run the experiments that
would falsify the hypotheses — the energies are too high, the
accelerators too expensive, and so on.

Now biology is heading in the same direction. The models we were
taught in school about "dominant" and "recessive" genes steering a
strictly Mendelian process have turned out to be an even greater
simplification of reality than Newton's laws. The discovery of
gene-protein interactions and other aspects of epigenetics has
challenged the view of DNA as destiny and even introduced evidence
that environment can influence inheritable traits, something once
considered a genetic impossibility.

In short, the more we learn about biology, the further we find
ourselves from a model that can explain it.

There is now a better way. Petabytes allow us to say: "Correlation is
enough." We can stop looking for models. We can analyze the data
without hypotheses about what it might show. We can throw the numbers
into the biggest computing clusters the world has ever seen and let
statistical algorithms find patterns where science cannot.

The best practical example of this is the shotgun gene sequencing by
J. Craig Venter. Enabled by high-speed sequencers and supercomputers
that statistically analyze the data they produce, Venter went from
sequencing individual organisms to sequencing entire ecosystems. In
2003, he started sequencing much of the ocean, retracing the voyage of
Captain Cook. And in 2005 he started sequencing the air. In the
process, he discovered thousands of previously unknown species of
bacteria and other life-forms.

If the words "discover a new species" call to mind Darwin and drawings
of finches, you may be stuck in the old way of doing science. Venter
can tell you almost nothing about the species he found. He doesn't
know what they look like, how they live, or much of anything else
about their morphology. He doesn't even have their entire genome. All
he has is a statistical blip — a unique sequence that, being unlike
any other sequence in the database, must represent a new species.

This sequence may correlate with other sequences that resemble those
of species we do know more about. In that case, Venter can make some
guesses about the animals — that they convert sunlight into energy in
a particular way, or that they descended from a common ancestor. But
besides that, he has no better model of this species than Google has
of your MySpace page. It's just data. By analyzing it with
Google-quality computing resources, though, Venter has advanced
biology more than anyone else of his generation.

This kind of thinking is poised to go mainstream. In February, the
National Science Foundation announced the Cluster Exploratory, a
program that funds research designed to run on a large-scale
distributed computing platform developed by Google and IBM in
conjunction with six pilot universities. The cluster will consist of
1,600 processors, several terabytes of memory, and hundreds of
terabytes of storage, along with the software, including Google File
System, IBM's Tivoli, and an open source version of Google's
MapReduce. Early CluE projects will include simulations of the brain
and the nervous system and other biological research that lies
somewhere between wetware and software.

Learning to use a "computer" of this scale may be challenging. But the
opportunity is great: The new availability of huge amounts of data,
along with the statistical tools to crunch these numbers, offers a
whole new way of understanding the world. Correlation supersedes
causation, and science can advance even without coherent models,
unified theories, or really any mechanistic explanation at all.

There's no reason to cling to our old ways. It's time to ask: What can
science learn from Google?

Chris Anderson ([EMAIL PROTECTED]) is the editor in chief of Wired.

-- 
Ted Pedersen
http://www.d.umn.edu/~tpederse

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