Alternatively, you can express the metabolites in microgram-equivalents of the parent
-----Original Message----- From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On Behalf Of [EMAIL PROTECTED] Sent: Tuesday, February 13, 2007 15:02 To: Nmusers (E-mail); [EMAIL PROTECTED] Subject: RE: [NMusers] Simultaneous drug and metabolite POPPK I have a question for those who submitted these two examples - Did you transform the data into micromolar quantities? It is not clear from the examples. I have not done much parent/metabolite modeling (just lucky I guess) but it seems to me that one would have to work in molar units for these models to be valid. Can someone comment on this? Mike ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Michael J. Fossler, Pharm. D., Ph. D., F.C.P. Director Clinical Pharmacokinetics, Modeling & Simulation GlaxoSmithKline (610) 270 - 4797 FAX: (610) 270-5962 Cell: (443) 350-1194 [EMAIL PROTECTED] ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ --------------------------------------------------------- Legal Notice: This electronic mail and its attachments are intended solely for the person(s) to whom they are addressed and contain information which is confidential or otherwise protected from disclosure, except for the purpose for which they are intended. Dissemination, distribution, or reproduction by anyone other than the intended recipients is prohibited and may be illegal. If you are not an intended recipient, please immediately inform the sender and return the electronic mail and its attachments and destroy any copies which may be in your possession. UCB screens electronic mails for viruses but does not warrant that this electronic mail is free of any viruses. UCB accepts no liability for any damage caused by any virus transmitted by this electronic mail. ---------------------------------------------------------
