Navin, If you are using an N-1 ODE model, and want the area under the compartment 1 concentration-time curve, add a differential equation of the form: DADT(N)= A(1)/V1 Then, A(N) provides the area under the concentration-time curve for compartment 1.
(If you do not have an ODE model, I would probably integrate the concentration curve by hand and simply compute in NONMEM.) I hope this helps, David Salinger Resource facility for Population Kinetics (RFPK) Dept. of Bioenginerring, University of Washington, Seattle On Thu, 15 Feb 2007, navin goyal wrote:
Hello everyone, As a part of the simulations I was trying to perform using nonmem, I have a pkpd model. I have a Pharmacodynamic endpoint and was wondering if I could integrate the area under the curve of this endpoint for some time period, (say like AUC for this effect for last 24 hrs ) I guess i could do it in excel (or someone suggested me using SAS). Could I do this in NONMEM? any help would be appreciated. Thanks Navin
