It does seem as though PREDPP should allow doses to be given at a certain small interval yet the entire sequence is lagged by a larger amount of time. If you can do this with a series of dose records, then the ADDL feature should be usable to do the same thing. The question is: Does this restriction represent a genuine impossibility (e.g., it can't be made to work because of some difficulty in the math), or was it a programming problem (too difficult to implement), or just a lapse in thinking on my part many years ago? I have to go back and review the code and some old memos, and try to reconstruct what the issue was. This may take me a week or two because I am traveling right now, but I will look at it when I can and will report back to the group.
On Mon, 2 Apr 2007 08:28:05 -0400, "Bachman, William (MYD)" <[EMAIL PROTECTED]> said: > My guess is that the software designer simply did not include this > functionality. When you are engineering software there are a number of > factors that come into play: > > 1. is a given feature plausible? > 2. is the probability of anyone needing this feature high? > 3. what is the difficulty of adding this feature? (from easy no-brainer > to exceedingly difficult and not worth the effort). > 4. does the addition of the feature run the chance of breaking a lot of > the currently working features? > > The above comments are given without reference to "lag time should not > exceed the (length of the) interdose interval" but are meant to point > out that although a given user may desire a specific item, more goes > into the decision than the users specific need. > > ________________________________ > > From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] > On Behalf Of Samtani, Mahesh [PRDUS] > Sent: Saturday, March 31, 2007 6:04 PM > To: [email protected] > Subject: [NMusers] Absorption delay NOT completed before the next dose > is given > > > Dear NM users, > > NM help files says the following about ALAG > > > > "When additional doses are specified on a dose event record, the > absorption lag time applies to the dose and to all the additional doses. > In this case the lag time should not exceed the (length of the) > interdose interval" > > > > My questions are > a) Why doesn't ADDL work for the above specific case? > b) I am running linear models with ADVAN2 and ADVAN5 and absorption > delay is NOT completed before the next dose is given. Due to the problem > stated above I am not using ADDL. Instead I have a dosing record at > every time a dose enters the depot compartment. Will this circumvent the > problem stated above? In other words does ALAG always have to be smaller > than II and why? > > > > Please advice...MNS > > > > > > > > > > > > > _______________________________________________________________________________________________________________________________________ > > > > > This e-mail transmission may contain confidential or legally privileged > information that is intended only for the individual or entity named in > the e-mail address. If you > are not the intended recipient, you are hereby notified that any > disclosure, copying, distribution, or reliance upon the contents of this > e-mail is strictly prohibited. > If you have received this e-mail transmission in error, please reply to > the sender, so that ICON can arrange for proper delivery, and then please > delete the message. Thank You. > > > > > > > > > > > -- Alison Boeckmann [EMAIL PROTECTED]
