maybe I am missing something here, but, why don't you parameterize your model in terms of half-life and put BATCH as a covariate on half-life?
________________________________ From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On Behalf Of [EMAIL PROTECTED] Sent: Thursday, April 19, 2007 10:54 AM To: [email protected] Subject: [NMusers] batches with different half-life - linear PK Hello NONMEM Users, Sometimes the same subjects receive the same drug from different batches. Potentially, half-life can be different accross batches. Theoretically, it is easy to model if PKis linear because NONMEM superimposes single-dose processes to obtain predicted concentrations for multiple doses. Does enyone know how to implement it in NONMEM? Are there any classes or publications which can help? Thanks! Pavel _______________________________________________________________________________________________________________________________________ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON can arrange for proper delivery, and then please delete the message. Thank You.
