If the number of data records for any individual exceeds 400, it is necessary to increase the size of certain buffers defined in SIZES. LIM1, LIM2, LIM6 and LIM16 should be given values that are larger than the maximum number of data records for an individual. Also, if the number of observation records for any individual exceeds 250, it is necessary to increase the value of NO in SIZES to exceed the maximum number of observation records for an individual. The value of LADD in SIZES should also be changed to exceed NO*(NO+1)/2 * (number of diagonal blocks of sigma) if L2 records are intraindividually correlated. The routines in the nm directory (standard installation) must be recompiled after changes to the LIM, NO and LADD values. The routines in the tr and tl directories must also be recompiled if the NO value is changes. Routines can be recompiled by deleting all the .obj files in the respective directories as well as nonmem.lib or nonmem.a in the nm directory and nmtran.exe in the tr directory and then rerunning the cdsetup6.bat installation script with the same arguments that were used for the original installation. Thanks to Dennis Fisher, P < (The "P Less Than" Company), for recommending this posting. Tom Ludden
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