Dear NONMEM users, I am working on a kinetic data set from automated peritoneal dialysis patients, with concentration measurements in plasma and dialysate. For the 24 h of this study, APD patients were placed on a standard dialysis prescription of three 2.5%, 2-L exchanges over a period of 8 h during the day using the cycler (automated session), followed by two 2.5%, 2-L dwells of about 8 h each over the course of the evening and overnight (manual session).
I think that Dialysis compartment have to be reset after exchanging dialysate. But it is difficult for me to prepare the data set. Could you explain the data preparation skill for peritoneal dialysis ? some data set is #ID TIME EVID DWEL DV CMT AMT 1 9:33 4 0 0 1 795 <-- Drug administration (IV bolus) 1 10:30 0 1 104.15 1 0 <-- Plasma concentration on 1 dwell (APD) 1 11:00 0 1 103.54 1 0 1 11:15 0 1 2.82 2 0 <-- Dialysate concentration on 1 dwell (APD) 1 12:20 0 1 11.92 2 0 1 12:30 0 1 84.77 1 0 1 13:10 0 2 78.3 1 0 <-- Plasma concentration on 2 dwell (APD) 1 13:40 0 2 76.02 1 0 1 13:56 0 2 2.9 2 0 <-- Dialysate concentration on 2 dwell (APD) 1 15:00 0 2 12.88 2 0 1 15:11 0 2 69.52 1 0 1 15:52 0 3 66.19 1 0 <-- Plasma concentration on 3 dwell (APD) 1 16:20 0 3 65.11 1 0 1 16:39 0 3 4.25 2 0 <-- Dialysate concentration on 3 dwell (APD) 1 17:45 0 3 11.99 2 0 1 17:50 0 3 62.36 1 0 1 22:00 0 4 48.91 1 0 <-- Plasma concentration on 4 dwell (PD) 1 26:00 0 4 41.55 1 0 1 26:17 0 4 22.56 2 0 <-- Dialysate concentration on 4 dwell (PD) 1 28:12 0 5 33 1 0 <-- Plasma concentration on 5 dwell (PD) 1 34:00 0 5 26.99 1 0 1 34:30 0 5 13.79 2 0 <-- Dialysate concentration on 5 dwell (PD) Each Dwell's start and end time is 1st : start 10:10 1st : end 12:40 2nd : start 12:40 2nd : end 15:24 3rd : start 15:24 3rd : end 18:09 4th : start 18:11 4th : end 26:16 5th : start 26:26 5th : end 34:20 Thank you for the help. Best wishes Min-Gul Kim --- Min-Gul Kim, MD, MS Research Doctor of Dept of Clinical Pharmacology Seoul National University Hospital, 28 Yeongeon-Dong Jongno-Gu, Seoul 110-744 Republic of Korea Tel: 82-2-740-8290, Fax: 82-2-742-9252
