Hi Mahesh, For compliant patients, you may use ADDL, II and SS simultaneously. Assuming you have same dose type (dose, II) for additional doses. For non-compliant patients who skipped the dose(s), I would add dose event record(s) after you the steady state dosing. For non-compliant patients who doubled the dose(s), then you may use SS=2.
The following is an example I found from Sheiner's training material which took place ~10 years ago. TIME AMT RATE SS II 50 20 . 0 . 64 10 . 2 8 a 10 mg bolus dose every 8 hrs, steady-state at 64 hrs, superimposed on a 20 mg bolus dose at 50 hours. I hope this helps. Joseph Joseph Kim, Ph.D., RPh. Principal Clinical Pharmacokineticist CPK/Modelling & Simulation GlaxoSmithKline Research Triangle Park North Carolina 27709 U.S.A. "Samtani, Mahesh [PRDUS]" <[EMAIL PROTECTED]> Sent by: [EMAIL PROTECTED] 02-Jan-2008 12:43 To [email protected] cc Subject [NMusers] Is the use of II, SS, and ADDL allowed simultaneously Dear NMusers, Is the use of II, SS, and ADDL allowed simultaneously in NONMEM? I wish to assess PK profiles at SS with and without compliance. Here is the potential scenario I am interested in: i) Patients come in at SS and take their 1st two doses correctly ii) Patients then remain compliant OR miss a dose OR ingest a double dose iii) Patients then resume taking their doses correctly For (i) I will need II, SS and ADDL For (ii) I don?t need any II or SS or ADDL For (iii) I will need II and ADDL Kindly advice?Mahesh PS. I am aware that I can hard code (formatting via S-plus etc) each dose after the first SS dose as a separate dosing record but I wish to know if there is an easier method available
