Dear Katharina, Please see the best practices posting by Dr. Kowalski on nmusers, which contains some references: <http://www.cognigencorp.com/nonmem/nm/99may012003.html> http://www.cognigencorp.com/nonmem/nm/99may012003.html
The second useful resource is Dr. Bonate's text-book (Pharmacokinetic-Pharmacodynamic Modeling And Simulation By Peter L. Bonate) where you can find a discussion around condition numbers on page 211. The simulation exercise described in the text-book is summarized in one of Dr. Bonate's posting at the following URL: <http://www.cognigencorp.com/nonmem/nm/99oct022002.html> http://www.cognigencorp.com/nonmem/nm/99oct022002.html Best wishes...MNS -----Original Message----- From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] Behalf Of "Katharina Küster" Sent: Monday, February 11, 2008 10:10 AM To: [email protected] Subject: [NMusers] Condition numbers and eigenvalues Dear nmusers, could anybody provide me with references about condition numbers and eigenvalues? I already know how to calculate them and I'm especially interested in how to judge the results. Thanks and best regards, Kati ______________________________ Katharina Kuester Pharmacist, PhD student Freie Universitaet Berlin Institute of Pharmacy Dept. Clinical Pharmacy Kelchstr. 31 D-12169 Berlin Phone: +49-30-838 506 27 Fax: +49-30-838 507 11 e-mail: [EMAIL PROTECTED]
