Huali,
This sounds like an ideal data set to determine if there are any effects
of genotype on CL/F. You dont really need NONMEM - just look at the
doserate/conc (i.e. CL/F) means for each genotype and do an ANOVA. Of
course you can make it fancier and include other covariates such as
weight, sex (a genotype), race etc. It can be done with NONMEM or almost
any statistics package that supports multiple regression.
Nick
Huali Wu wrote:
Dear all:
I am trying to figure out if there is any effect of enzyme genotype on
the PK of a drug and its active metabolites. But I don't know if I
could use NONMEM to do this with my data.
I have a dataset from multiple dose study. Drug was administered
orally and only one sample was taken from each patient at steady
state. Parent drug and three metabolites concentrations were measured.
Each patient was genotyped. Time since last dose was not recorded
because the maximum concentration and trough concentration varied only
3%.
Could NONMEM be used for this analysis? Any comment will be highly
appreciated.
Best regards,
Huali
--
Nick Holford, Dept Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL PROTECTED] tel:+64(9)373-7599x86730 fax:+64(9)373-7090
www.health.auckland.ac.nz/pharmacology/staff/nholford
