You will probably have to write your own model.
One suggested model would be:
V = Vmax x S/[Km + S x (1 + S/Ki)]
Where
V = velocity,
S = substrate concentration,
km = substrate concentration at half maximal velocity
ki = inhibition constant
Vmax = maximal velocity
See:
Mutlib AE GT, Bauman JN, Williams JA, Kulkarni S, Kostrubsky S.
Kinetics of acetaminophen glucuronidation by
UDP-glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential
implications in acetaminophen-induced hepatotoxicity. Chem Res
Toxicol. 2006;19(5):701-709.
Regards
David
At 09:06 a.m. 6/6/2008, Yuyan Jin wrote:
Hi Dear Nonmem user,
I am trying to model the kinetics of a compound that exhibits enzyme
auto-inhibition.I have found some previously suggested literature by
nonmem users, but all of them were auto-induction cases. Does
anyone know any enzyme auto-inhibition PK model paper published ?
Thanks so much!
Sincerely,
Yuyan Jin
Graduate student
University of Pittsburgh
Dr David Reith MBBS FRACP MMedSc(Pharm) PhD
Associate Professor
Dunedin School of Medicine
University of Otago
New Zealand
Phone: +64 3 4740999 Fax: +64 3 4747817
