Dear Galadriel:
You would need to provide an estimate of D2, the duration of zero-order
input to CMT=2 in your model.
Sam Liao
Pharmax Research
Dear all,
I tried to build up a combined absorption model (zero order + first
order)using ADVAN 4, following is the control file I found in the
PDx-pop library,
...........
CL=THETA(1)*EXP(ETA(1))
V2=THETA(2)*EXP(ETA(2))
Q =THETA(3)*EXP(ETA(3))
V3=THETA(4)*EXP(ETA(4))
KA=THETA(5)*EXP(ETA(5))
R2=THETA(6)*EXP(ETA(6))
F1=EXP(THETA(7)+ETA(7))/(1+EXP(THETA(7)+ETA(7)))
F2=1-F1
S2=V2
.................
and for each dose record, an additional IV adminstration dose record
is inserted with same dosage & rate=-2
ID TIME AMT DV CMT RATE........
1 0 100 . 1 0 .........
1 0 100 . 2 -2 .........
An error message is reported 'PK PARAMETER FOR DURATION IS NOT
SUPPLIED BY PK FOR COMPT. NO. 2'.
So is it the proper way to code the data? How can I estimate combined
absorption model without using the differiential equation?
Many thanks for your help!
BR,
Galadriel
